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| http://purl.uniprot.org/citations/16968699 | http://www.w3.org/2000/01/rdf-schema#comment | "WASP family proteins are key players for connecting multiple signaling pathways to F-actin polymerization. To dissect the highly integrated signaling pathways controlling WASP activity, we identified a Rac protein that binds to the GTPase binding domain of WASP. Using two-hybrid and FRET-based functional assays, we identified RacC as a major regulator of WASP. RacC stimulates F-actin assembly in cell-free systems in a WASP-dependent manner. A FRET-based microscopy approach showed local activation of RacC at the leading edge of chemotaxing cells. Cells overexpressing RacC exhibit a significant increase in the level of F-actin polymerization upon cAMP stimulation, which can be blocked by a phosphatidylinositol (PI) 3-kinase inhibitor. Membrane translocation of PI 3-kinase and PI 3,4,5-trisphosphate reporter is absent in racC null cells. Cells overexpressing dominant negative RacC mutants and racC null cells move at a significantly slower speed and show a poor directionality during chemotaxis. Our results suggest that RacC plays an important role in PI 3-kinase activation and WASP activation for dynamic regulation of F-actin assembly during Dictyostelium chemotaxis."xsd:string |
| http://purl.uniprot.org/citations/16968699 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m605997200"xsd:string |
| http://purl.uniprot.org/citations/16968699 | http://purl.uniprot.org/core/author | "Rivero F."xsd:string |
| http://purl.uniprot.org/citations/16968699 | http://purl.uniprot.org/core/author | "Chung C.Y."xsd:string |
| http://purl.uniprot.org/citations/16968699 | http://purl.uniprot.org/core/author | "Han J.W."xsd:string |
| http://purl.uniprot.org/citations/16968699 | http://purl.uniprot.org/core/author | "Leeper L."xsd:string |
| http://purl.uniprot.org/citations/16968699 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16968699 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16968699 | http://purl.uniprot.org/core/pages | "35224-35234"xsd:string |
| http://purl.uniprot.org/citations/16968699 | http://purl.uniprot.org/core/title | "Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium."xsd:string |
| http://purl.uniprot.org/citations/16968699 | http://purl.uniprot.org/core/volume | "281"xsd:string |
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