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http://purl.uniprot.org/citations/16969646http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16969646http://www.w3.org/2000/01/rdf-schema#comment"

Aims/hypothesis

The receptor for AGE (RAGE) is considered to be mainly an intracellular signal-transducer or pro-inflammatory peptide of possible importance for inflammation and autoimmune diseases. Our aim was to study whether the -374 T/A polymorphism in the gene encoding RAGE (AGER) is associated with diabetes type and presence of diabetic complications.

Methods

The AGER -374 T/A polymorphism was genotyped in 867 type 1 diabetic patients, 2,467 type 2 diabetic patients and 205 non-diabetic control subjects of Scandinavian origin.

Results

AGER polymorphism was related to different HLA-DQB1 genotypes and the presence of diabetic complications. Type 1 diabetic patients had a higher frequency of the AGER -374 A/A or T/A genotypes than type 2 diabetic patients (51.1 vs 44.9%, p=0.002) and control subjects (51.1 vs 47.6%, p=0.0006). The RAGE -374 T/A polymorphism was associated with HLA-DQB1 genotypes; patients with HLA risk genotypes had a higher frequency of the A/A or T/A genotypes than patients with other HLA-DQB1 genotypes (60.3 vs 40.3%, p<0.000001). In type 1 diabetic patients, the frequency of the A/A or T/A genotypes was higher in patients with diabetic nephropathy than without (61.1 vs 46.8%, p=0.006) and with sight-threatening retinopathy than without (56.1 vs 47.6%, p=0.03). In type 2 diabetic patients with HbA(1c) values below the median, the T/T genotype was more frequent in patients with diabetic nephropathy than without (54.3 vs 38.2%, p=0.02).

Conclusions/interpretation

Our results show an association between the AGER -374 T/A polymorphism and type 1 diabetes. This association was HLA-DQB1-dependent. The polymorphism was associated with diabetic nephropathy in both type 1 and type 2 diabetes, in an HbA(1c)-dependent manner in the latter group, and also with sight-threatening retinopathy in type 1 diabetic patients."xsd:string
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http://purl.uniprot.org/citations/16969646http://purl.uniprot.org/core/author"Groop L."xsd:string
http://purl.uniprot.org/citations/16969646http://purl.uniprot.org/core/author"Sjogren M."xsd:string
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http://purl.uniprot.org/citations/16969646http://purl.uniprot.org/core/author"Cilio C.M."xsd:string
http://purl.uniprot.org/citations/16969646http://purl.uniprot.org/core/author"Agardh C.D."xsd:string
http://purl.uniprot.org/citations/16969646http://purl.uniprot.org/core/author"Agardh E."xsd:string
http://purl.uniprot.org/citations/16969646http://purl.uniprot.org/core/author"Bakhtadze E."xsd:string
http://purl.uniprot.org/citations/16969646http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16969646http://purl.uniprot.org/core/name"Diabetologia"xsd:string
http://purl.uniprot.org/citations/16969646http://purl.uniprot.org/core/pages"2745-2755"xsd:string
http://purl.uniprot.org/citations/16969646http://purl.uniprot.org/core/title"The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients."xsd:string
http://purl.uniprot.org/citations/16969646http://purl.uniprot.org/core/volume"49"xsd:string
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