| http://purl.uniprot.org/citations/16972255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16972255 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix Metalloproteinases (MMPs) are crucial enzymes for ultraviolet irradiation-induced photoaging in human skin. Ultraviolet B (UVB) stimulates dermal fibroblasts to increase MMP-1 and -3 expression and extracellular matrix (ECM) degradation in photoaging. We investigated whether phosphatase and tensin homolog (PTEN)/Akt pathway is involved in secretions of MMP-1 and -3 in human dermal fibroblasts. The increase in MMP-1 and -3 expression and secretion occurred along with the increase in PTEN and Akt phosphorylation by UVB irradiation in a dose- and time-dependent manner. However, treatment with a casein kinase 2 inhibitor, 5,6-dichloro-1-beta-D-ribofuranosyl-benzimidazole, inhibited their phosphorylations and MMP-1 and -3 secretions. Transfection of wild-type PTEN (Wt-PTEN) decreased basal and UVB-induced MMP-1 and -3 secretions, as well as activator protein-1 (AP-1) activity, while transfection of small interference RNA of PTEN (siRNA-PTEN), phosphatase-inactive PTEN (C124S-PTEN), or lipid phosphatase-inactive PTEN (G129E-PTEN) increased basal or UVB-induced MMP-1 and -3 secretions and AP-1 activity. Transfection of constitutively active Akt (Myr-Akt) also increased basal or UVB-induced MMP-1 and -3 secretions, as well as AP-1 activity. However, transfection of kinase-inactive Akt (K179M-Akt) decreased their secretions, but showed no significant change of AP-1 activity without UVB irradiation, and a significant increase of AP-1 activity with UVB irradiation. Treatment with the phosphatidylinositol 3-kinase inhibitors, LY294002 or wortmannin, downregulated basal and UVB-induced MMP-1 and -3 secretions. In conclusion, UVB irradiation increases PTEN and Akt phosphorylation in human dermal fibroblasts, and these inhibition of PTEN and activation of Akt by phosphorylation are involved in UVB-induced MMP-1 and -3 secretions partly through upregulation of AP-1 activity."xsd:string |
| http://purl.uniprot.org/citations/16972255 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.20754"xsd:string |
| http://purl.uniprot.org/citations/16972255 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/16972255 | http://purl.uniprot.org/core/author | "Kim A."xsd:string |
| http://purl.uniprot.org/citations/16972255 | http://purl.uniprot.org/core/author | "Oh J.H."xsd:string |
| http://purl.uniprot.org/citations/16972255 | http://purl.uniprot.org/core/author | "Park J.M."xsd:string |
| http://purl.uniprot.org/citations/16972255 | http://purl.uniprot.org/core/author | "Chung A.S."xsd:string |
| http://purl.uniprot.org/citations/16972255 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16972255 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/16972255 | http://purl.uniprot.org/core/pages | "775-785"xsd:string |
| http://purl.uniprot.org/citations/16972255 | http://purl.uniprot.org/core/title | "Ultraviolet B-induced matrix metalloproteinase-1 and -3 secretions are mediated via PTEN/Akt pathway in human dermal fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/16972255 | http://purl.uniprot.org/core/volume | "209"xsd:string |
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