| http://purl.uniprot.org/citations/16973388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16973388 | http://www.w3.org/2000/01/rdf-schema#comment | "Systemic lupus erythematosus (SLE) is characterized by the production of autoantibodies that are frequently directed against nucleic acid-associated antigens. To better understand how B cells reactive with such antigens are regulated, we generated a model system in which heavy and light chain genes encoding 564 immunoglobulin have been targeted to the heavy and light chain loci of the nonautoimmune C57BL/6 mouse strain. This antibody recognizes RNA, single-stranded DNA, and nucleosomes. We show that B cells expressing this immunoglobulin were activated, producing class-switched autoantibody in vivo despite the apparently normal induction of anergy. This autoantibody production was largely dependent on Toll-like receptor 7 (TLR7). We further show that production of these autoantibodies was sufficient to cause kidney pathology in these mice. These results demonstrate that the particular threat of nucleic acid-containing autoantigens lies in their ability to bind both antigen receptor and TLR7."xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2006.07.014"xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/author | "Han J.H."xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/author | "Fernandez L."xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/author | "Wortis H.H."xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/author | "Kearney J.F."xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/author | "Kari E."xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/author | "Imanishi-Kari T."xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/author | "Lomakin I."xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/author | "Berland R."xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/author | "Ucci A.A."xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/pages | "429-440"xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/title | "Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice."xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16973388 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16973388 |
| http://purl.uniprot.org/citations/16973388 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16973388 |
| http://purl.uniprot.org/uniprot/#_E0CXQ9-mappedCitation-16973388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16973388 |
| http://purl.uniprot.org/uniprot/#_A2AHJ1-mappedCitation-16973388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16973388 |
| http://purl.uniprot.org/uniprot/#_A2AHJ2-mappedCitation-16973388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16973388 |
| http://purl.uniprot.org/uniprot/#_B7ZMX3-mappedCitation-16973388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16973388 |
| http://purl.uniprot.org/uniprot/#_P58681-mappedCitation-16973388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16973388 |