| http://purl.uniprot.org/citations/1697583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1697583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1697583 | http://www.w3.org/2000/01/rdf-schema#comment | "We have isolated four insulin-like growth factor binding proteins (IGFBPs) from adult human serum by insulin-like growth factor (IGF) I affinity chromatography and high performance liquid chromatography. A 36-kDa binding protein (BP), not digestible with N-glycanase, is increased in patients with extrapancreatic tumor hypoglycemia and during IGF I administration in healthy adults. Its 38 NH2-terminal amino acids are identical to those of an IGFBP sequence derived from a human cDNA that cross-hybridizes with the rat IGFBP-2 cDNA. With probes encoding a NH2-terminal, COOH-terminal, and a middle region of this protein we have obtained three cDNA clones from a Hep G2 cDNA library; one encodes human IGFBP-2, and the other two presumably represent unspliced heteronuclear and alternatively spliced mRNA, respectively. A 28-30-kDa IGFBP represents a novel BP species in human serum. Its 30 NH2-terminal amino acids are not homologous to IGFBP-1, -2, or -3. It is not digestible with N-glycanase and does not bind 125I-IGF I. The NH2-terminal sequences of a 42/45- and a 31-kDa IGFBP are identical to that of human IGFBP-3. The 42/45-kDa proteins are two glycosylation variants of BP-3. The 31-kDa protein presumably is a degradation product of BP-3 that lacks the COOH terminus. It is likely that the different IGFBPs modulate auto-/paracrine and endocrine effects of IGFs on growth and metabolism in a different and specific manner."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)77200-1"xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)77200-1"xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Bauer D."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Bauer D."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Fischer J.A."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Fischer J.A."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Merryweather J."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Merryweather J."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Kiefer M."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Kiefer M."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Born W."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Born W."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Zapf J."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Zapf J."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Froesch E.R."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Froesch E.R."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Musiarz F."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/author | "Musiarz F."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/1697583 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |