| http://purl.uniprot.org/citations/16982417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16982417 | http://www.w3.org/2000/01/rdf-schema#comment | "Alzheimer's disease (AD) may result from the accumulation of amyloid-beta (Abeta) peptides in the brain. The cysteine protease cathepsin B (CatB) is associated with amyloid plaques in AD brains and has been suspected to increase Abeta production. Here, we demonstrate that CatB actually reduces levels of Abeta peptides, especially the aggregation-prone species Abeta1-42, through proteolytic cleavage. Genetic inactivation of CatB in mice with neuronal expression of familial AD-mutant human amyloid precursor protein (hAPP) increased the relative abundance of Abeta1-42, worsening plaque deposition and other AD-related pathologies. Lentivirus-mediated expression of CatB in aged hAPP mice reduced preexisting amyloid deposits, even thioflavin S-positive plaques. Under cell-free conditions, CatB effectively cleaved Abeta1-42, generating C-terminally truncated Abeta peptides that are less amyloidogenic. Thus, CatB likely fulfills antiamyloidogenic and neuroprotective functions. Insufficient CatB activity might promote AD; increasing CatB activity could counteract the neuropathology of this disease."xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2006.07.027"xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/author | "Arai H."xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/author | "Esposito L."xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/author | "Gan L."xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/author | "Sun B."xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/author | "Yu G."xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/author | "Roberson E.D."xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/author | "Mucke L."xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/author | "Mueller-Steiner S."xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/pages | "703-714"xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/title | "Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/16982417 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16982417 |
| http://purl.uniprot.org/citations/16982417 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16982417 |
| http://purl.uniprot.org/uniprot/#_E0CXT9-mappedCitation-16982417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16982417 |
| http://purl.uniprot.org/uniprot/#_E0CYH3-mappedCitation-16982417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16982417 |
| http://purl.uniprot.org/uniprot/#_E0CYJ9-mappedCitation-16982417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16982417 |
| http://purl.uniprot.org/uniprot/#_E0CX28-mappedCitation-16982417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16982417 |