| http://purl.uniprot.org/citations/16982830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16982830 | http://www.w3.org/2000/01/rdf-schema#comment | "CXCL16 is a recently discovered multifaceted chemokine that has been shown not only to recruit activated T lymphocytes but also to play a direct role in the binding and phagocytosis of bacteria by professional antigen-presenting cells. In this study, we investigated the role of CXCL16 in vivo in the regulation of the immune response using a murine model of Salmonella enterica serovar Enteritidis infection. The expression of CXCL16 was strongly upregulated in the spleens and livers of animals developing an immune response to a primary acute infection but not in the Peyer's patches. Animals developing a secondary response after reexposure to the bacteria displayed a similar pattern of expression. During the primary response, prior treatment with neutralizing antibodies to CXCL16 induced a significant increase in bacterial burden in the spleen and liver. The production of gamma interferon (IFN-gamma) by the lymphocytes in the spleen was decreased by anti-CXCL16 treatment. In comparison, during the secondary response, anti-CXCL16 treatment also significantly increased bacterial burden in both the spleen and liver but had no effect on IFN-gamma production. No role was found for CXCL16 in the production of antibody against SefA, a major surface antigen of S. enteritidis. Together, these results demonstrate a role for CXCL16 in the control of bacterial colonization of target organs and, more specifically, in the regulation of the cell-mediated arm of the primary response to S. enteritidis."xsd:string |
| http://purl.uniprot.org/citations/16982830 | http://purl.org/dc/terms/identifier | "doi:10.1128/iai.01065-06"xsd:string |
| http://purl.uniprot.org/citations/16982830 | http://purl.uniprot.org/core/author | "McColl S.R."xsd:string |
| http://purl.uniprot.org/citations/16982830 | http://purl.uniprot.org/core/author | "Fahy O.L."xsd:string |
| http://purl.uniprot.org/citations/16982830 | http://purl.uniprot.org/core/author | "Townley S.L."xsd:string |
| http://purl.uniprot.org/citations/16982830 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16982830 | http://purl.uniprot.org/core/name | "Infect Immun"xsd:string |
| http://purl.uniprot.org/citations/16982830 | http://purl.uniprot.org/core/pages | "6885-6894"xsd:string |
| http://purl.uniprot.org/citations/16982830 | http://purl.uniprot.org/core/title | "CXCL16 regulates cell-mediated immunity to Salmonella enterica serovar Enteritidis via promotion of gamma interferon production."xsd:string |
| http://purl.uniprot.org/citations/16982830 | http://purl.uniprot.org/core/volume | "74"xsd:string |
| http://purl.uniprot.org/citations/16982830 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16982830 |
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