| http://purl.uniprot.org/citations/16982880 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16982880 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunological memory is associated with the display of improved effector functions. The maintenance by CD8 memory cells of high levels of untranslated CCL5 mRNA allows these cells to immediately secrete this chemokine upon Ag stimulation. Untranslated mRNA storage is a newly described process supporting the immediate display of an effector function by memory lymphocytes. We have tested the capacity of different cytokines to regulate the memorization of CCL5 by memory CD8 T cells. We found that IL-4 treatment of murine CD8 T cells impairs immediate CCL5 secretion capacity by inhibiting CCL5 mRNA transcription through a STAT6-dependent pathway. The inhibition by IL-4 is reversible, as memory CD8 T cells reconstitute their CCL5 mRNA stores and reacquire their immediate CCL5 secretion capacity when IL-4 is withdrawn. This recovery is cell autonomous because it proceeds in culture medium in the absence of exogenous growth factors, suggesting that CCL5 expression by memory CD8 T cells is a default process. Overall, these results indicate that the expression of CCL5 is an intrinsic property acquired by memory CD8 T cells that is regulated by environmental factors."xsd:string |
| http://purl.uniprot.org/citations/16982880 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.7.4451"xsd:string |
| http://purl.uniprot.org/citations/16982880 | http://purl.uniprot.org/core/author | "Walzer T."xsd:string |
| http://purl.uniprot.org/citations/16982880 | http://purl.uniprot.org/core/author | "Marcais A."xsd:string |
| http://purl.uniprot.org/citations/16982880 | http://purl.uniprot.org/core/author | "Marvel J."xsd:string |
| http://purl.uniprot.org/citations/16982880 | http://purl.uniprot.org/core/author | "Ghittoni R."xsd:string |
| http://purl.uniprot.org/citations/16982880 | http://purl.uniprot.org/core/author | "Tomkowiak M."xsd:string |
| http://purl.uniprot.org/citations/16982880 | http://purl.uniprot.org/core/author | "Coupet C.A."xsd:string |
| http://purl.uniprot.org/citations/16982880 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16982880 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16982880 | http://purl.uniprot.org/core/pages | "4451-4457"xsd:string |
| http://purl.uniprot.org/citations/16982880 | http://purl.uniprot.org/core/title | "Cell-autonomous CCL5 transcription by memory CD8 T cells is regulated by IL-4."xsd:string |
| http://purl.uniprot.org/citations/16982880 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/16982880 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16982880 |
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