| http://purl.uniprot.org/citations/16983341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16983341 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatocyte growth factor activator inhibitor-1 (HAI-1) is a Kunitz-type transmembrane serine protease inhibitor that forms inhibitor complexes with several trypsin-like serine proteases and is required for mouse placental development and embryo survival. Here we show that the essential function of HAI-1 in placentation and all other embryonic processes is to restrict the activity of the type II transmembrane serine protease, matriptase. Enzymatic gene trapping of matriptase combined with HAI-1 immunohistochemistry revealed that matriptase is co-expressed with HAI-1 in both extraembryonic and embryonic tissues. As early as embryonic day 8.5, matriptase and HAI-1 were expressed in a population of chorionic trophoblasts. Ablation of HAI-1 disrupted the epithelial integrity of this cell population, causing disorganized laminin deposition and altered expression of E-cadherin and beta-catenin. This led to a complete loss of undifferentiated chorionic trophoblasts after embryonic day 9.5 and prevented the formation of the placental labyrinth. Genetic ablation of matriptase activity in HAI-1-deficient embryos, however, restored the integrity of chorionic trophoblasts and enabled placental labyrinth formation and development to term. Furthermore, matriptase/HAI-1 double-deficient mice were phenotypically indistinguishable from matriptase single-deficient littermates."xsd:string |
| http://purl.uniprot.org/citations/16983341 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1209966"xsd:string |
| http://purl.uniprot.org/citations/16983341 | http://purl.uniprot.org/core/author | "Bugge T.H."xsd:string |
| http://purl.uniprot.org/citations/16983341 | http://purl.uniprot.org/core/author | "Szabo R."xsd:string |
| http://purl.uniprot.org/citations/16983341 | http://purl.uniprot.org/core/author | "List K."xsd:string |
| http://purl.uniprot.org/citations/16983341 | http://purl.uniprot.org/core/author | "Molinolo A."xsd:string |
| http://purl.uniprot.org/citations/16983341 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/16983341 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/16983341 | http://purl.uniprot.org/core/pages | "1546-1556"xsd:string |
| http://purl.uniprot.org/citations/16983341 | http://purl.uniprot.org/core/title | "Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development."xsd:string |
| http://purl.uniprot.org/citations/16983341 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/16983341 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16983341 |
| http://purl.uniprot.org/citations/16983341 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16983341 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-16983341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16983341 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SU89-mappedCitation-16983341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16983341 |
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| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-16983341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16983341 |
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| http://purl.uniprot.org/uniprot/#_D3YUH4-mappedCitation-16983341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16983341 |