| http://purl.uniprot.org/citations/16987966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16987966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16987966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16987966 | http://www.w3.org/2000/01/rdf-schema#comment | "The order Nidovirales comprises viruses from the families Coronaviridae (genera Coronavirus and Torovirus), Roniviridae (genus Okavirus), and Arteriviridae (genus Arterivirus). In this study, we characterized White bream virus (WBV), a bacilliform plus-strand RNA virus isolated from fish. Analysis of the nucleotide sequence, organization, and expression of the 26.6-kb genome provided conclusive evidence for a phylogenetic relationship between WBV and nidoviruses. The polycistronic genome of WBV contains five open reading frames (ORFs), called ORF1a, -1b, -2, -3, and -4. In WBV-infected cells, three subgenomic RNAs expressing the structural proteins S, M, and N were identified. The subgenomic RNAs were revealed to share a 42-nucleotide, 5' leader sequence that is identical to the 5'-terminal genome sequence. The data suggest that a conserved nonanucleotide sequence, CA(G/A)CACUAC, located downstream of the leader and upstream of the structural protein genes acts as the core transcription-regulating sequence element in WBV. Like other nidoviruses with large genomes (>26 kb), WBV encodes in its ORF1b an extensive set of enzymes, including putative polymerase, helicase, ribose methyltransferase, exoribonuclease, and endoribonuclease activities. ORF1a encodes several membrane domains, a putative ADP-ribose 1"-phosphatase, and a chymotrypsin-like serine protease whose activity was established in this study. Comparative sequence analysis revealed that WBV represents a separate cluster of nidoviruses that significantly diverged from toroviruses and, even more, from coronaviruses, roniviruses, and arteriviruses. The study adds to the amazing diversity of nidoviruses and appeals for a more extensive characterization of nonmammalian nidoviruses to better understand the evolution of these largest known RNA viruses."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01758-06"xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01758-06"xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01758-06"xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Hoffmann B."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Hoffmann B."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Hoffmann B."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Bayer S."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Bayer S."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Bayer S."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Mettenleiter T.C."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Mettenleiter T.C."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Mettenleiter T.C."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Schelle B."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Schelle B."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Schelle B."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Ziebuhr J."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Ziebuhr J."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Ziebuhr J."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Ulferts R."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Ulferts R."xsd:string |
| http://purl.uniprot.org/citations/16987966 | http://purl.uniprot.org/core/author | "Ulferts R."xsd:string |