| http://purl.uniprot.org/citations/16990140 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16990140 | http://www.w3.org/2000/01/rdf-schema#comment | "Ca(2+) binding to synaptotagmin 1 triggers fast exocytosis of synaptic vesicles that have been primed for release by SNARE-complex assembly. Besides synaptotagmin 1, fast Ca(2+)-triggered exocytosis requires complexins. Synaptotagmin 1 and complexins both bind to assembled SNARE complexes, but it is unclear how their functions are coupled. Here we propose that complexin binding activates SNARE complexes into a metastable state and that Ca(2+) binding to synaptotagmin 1 triggers fast exocytosis by displacing complexin from metastable SNARE complexes. Specifically, we demonstrate that, biochemically, synaptotagmin 1 competes with complexin for SNARE-complex binding, thereby dislodging complexin from SNARE complexes in a Ca(2+)-dependent manner. Physiologically, increasing the local concentration of complexin selectively impairs fast Ca(2+)-triggered exocytosis but retains other forms of SNARE-dependent fusion. The hypothesis that Ca(2+)-induced displacement of complexins from SNARE complexes triggers fast exocytosis accounts for the loss-of-function and gain-of-function phenotypes of complexins and provides a molecular explanation for the high speed and synchronicity of fast Ca(2+)-triggered neurotransmitter release."xsd:string |
| http://purl.uniprot.org/citations/16990140 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.08.030"xsd:string |
| http://purl.uniprot.org/citations/16990140 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/16990140 | http://purl.uniprot.org/core/author | "Dai H."xsd:string |
| http://purl.uniprot.org/citations/16990140 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/16990140 | http://purl.uniprot.org/core/author | "Rizo J."xsd:string |
| http://purl.uniprot.org/citations/16990140 | http://purl.uniprot.org/core/author | "Maximov A."xsd:string |
| http://purl.uniprot.org/citations/16990140 | http://purl.uniprot.org/core/author | "Shin O.H."xsd:string |
| http://purl.uniprot.org/citations/16990140 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16990140 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16990140 | http://purl.uniprot.org/core/pages | "1175-1187"xsd:string |
| http://purl.uniprot.org/citations/16990140 | http://purl.uniprot.org/core/title | "A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis."xsd:string |
| http://purl.uniprot.org/citations/16990140 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/16990140 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16990140 |
| http://purl.uniprot.org/citations/16990140 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16990140 |
| http://purl.uniprot.org/uniprot/#_P63040-mappedCitation-16990140 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16990140 |
| http://purl.uniprot.org/uniprot/#_H6RXZ1-mappedCitation-16990140 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16990140 |
| http://purl.uniprot.org/uniprot/#_P46096-mappedCitation-16990140 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16990140 |
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| http://purl.uniprot.org/uniprot/P63040 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16990140 |
| http://purl.uniprot.org/uniprot/H6RXZ1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16990140 |
| http://purl.uniprot.org/uniprot/P46096 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16990140 |
| http://purl.uniprot.org/uniprot/Q3TPT3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16990140 |