| http://purl.uniprot.org/citations/16990252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16990252 | http://www.w3.org/2000/01/rdf-schema#comment | "Beta-catenin mediates Wnt/wingless signaling and transcriptional activation by lymphocyte enhancer binding factor 1/T cell factor (LEF1/TCF) proteins with the assistance of multiple coregulators, including positive cofactors like p300/CBP and negative cofactors like HDACs. We previously demonstrated that a developmentally essential protein, Flightless-I (Fli-I), serves as a coactivator for nuclear receptor-mediated transcription. To further understand the action mechanism of Fli-I, we investigated the functional roles of Fli-I and Fli-I leucine rich repeat associated protein 1 (FLAP1) in transcriptional activation by beta-catenin and LEF1/TCF. beta-catenin-dependent transcription was activated by exogenous FLAP1 but inhibited by Fli-I. Reduction of endogenous FLAP1 levels compromised transcriptional activation by LEF1/TCF, beta-catenin and the p160 coactivator GRIP1. FLAP1 interacted directly with beta-catenin, GRIP1 and p300 and enhanced their activity. Furthermore, FLAP1 was strongly synergistic with p300 in supporting transcriptional activation by beta-catenin and LEF1/TCF, but Fli-I disrupted the synergy of FLAP1 with p300 and beta-catenin. Thus the opposing effects of Fli-I and FLAP1 may be a key regulatory mechanism for beta-catenin and LEF1/TCF-mediated transcription and thus for Wnt signaling, and some mutations of Fli-I may result in developmental defects, such as the flightless phenotype of Drosophila, by causing dysregulation of the Wnt/beta-catenin pathway."xsd:string |
| http://purl.uniprot.org/citations/16990252 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkl652"xsd:string |
| http://purl.uniprot.org/citations/16990252 | http://purl.uniprot.org/core/author | "Lee Y.H."xsd:string |
| http://purl.uniprot.org/citations/16990252 | http://purl.uniprot.org/core/author | "Stallcup M.R."xsd:string |
| http://purl.uniprot.org/citations/16990252 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16990252 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/16990252 | http://purl.uniprot.org/core/pages | "5052-5059"xsd:string |
| http://purl.uniprot.org/citations/16990252 | http://purl.uniprot.org/core/title | "Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription."xsd:string |
| http://purl.uniprot.org/citations/16990252 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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