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http://purl.uniprot.org/citations/16991088http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16991088http://www.w3.org/2000/01/rdf-schema#comment"

Background

Although meningitis is the most severe form of infection caused by Mycobacterium tuberculosis, the immunopathogenesis of this disease is poorly understood. We tested the hypothesis that polymorphisms in Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP), an adaptor protein that mediates signals from Toll-like receptors activated by mycobacteria, are associated with susceptibility to tuberculosis (TB).

Methods

We used a case-population study design in Vietnam with cord-blood control samples (n = 392) and case patients (n = 358) who had either pulmonary (n = 183) or meningeal (n = 175) TB.

Results

The TIRAP single-nucleotide polymorphism (SNP) C558T was associated with increased susceptibility to TB, with a 558T allele frequency of 0.035 in control samples versus 0.074 in case patients (odds ratio [OR], 2.25; P < .001). Subgroup analysis revealed that SNP 558T was more strongly associated with susceptibility to meningeal TB (OR, 3.02; P < .001) than to pulmonary TB (OR, 1.55; P = .22). In comparison to the 558CC genotype, the 558TT genotype was associated with decreased whole-blood interleukin-6 production, which suggests that TIRAP influences disease susceptibility by modulating the inflammatory response.

Conclusions

These results provide the first evidence of an association of a TIRAP SNP with the risk of any disease and also suggest that the Toll-like receptor pathway influences susceptibility to meningeal and pulmonary TB by different immune mechanisms."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.org/dc/terms/identifier"doi:10.1086/507907"xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Hien T.T."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Rodrigues S."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Simmons C.P."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Aderem A."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Zhao L.P."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Dunstan S.J."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Hawn T.R."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Farrar J.J."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Thwaites G.E."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Lan N.T.N."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Hieu N.T."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Chau T.T.H."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Thuong N.T."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Janer M."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/author"Quy H.T."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/name"J Infect Dis"xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/pages"1127-1134"xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/title"A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis."xsd:string
http://purl.uniprot.org/citations/16991088http://purl.uniprot.org/core/volume"194"xsd:string
http://purl.uniprot.org/citations/16991088http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16991088
http://purl.uniprot.org/citations/16991088http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16991088
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