| http://purl.uniprot.org/citations/17000875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17000875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17000875 | http://www.w3.org/2000/01/rdf-schema#comment | "Small ubiquitin-related modifier (SUMO) processing and deconjugation are mediated by sentrin-specific proteases/ubiquitin-like proteases (SENP/Ulps). We show that SUMO-specific protease 1 (SUSP1), a mammalian SENP/Ulp, localizes within the nucleoplasm. SUSP1 depletion within cell lines expressing enhanced green fluorescent protein (EGFP) fusions to individual SUMO paralogues caused redistribution of EGFP-SUMO2 and -SUMO3, particularly into promyelocytic leukemia (PML) bodies. Further analysis suggested that this change resulted primarily from a deficit of SUMO2/3-deconjugation activity. Under these circumstances, PML bodies became enlarged and increased in number. We did not observe a comparable redistribution of EGFP-SUMO1. We have investigated the specificity of SUSP1 using vinyl sulfone inhibitors and model substrates. We found that SUSP1 has a strong paralogue bias toward SUMO2/3 and that it acts preferentially on substrates containing three or more SUMO2/3 moieties. Together, our findings argue that SUSP1 may play a specialized role in dismantling highly conjugated SUMO2 and -3 species that is critical for PML body maintenance."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200510103"xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200510103"xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Azuma Y."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Azuma Y."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Mukhopadhyay D."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Mukhopadhyay D."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Ayaydin F."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Ayaydin F."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Wilkinson K.D."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Wilkinson K.D."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Dasso M."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Dasso M."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Kametaka A."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Kametaka A."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Kolli N."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Kolli N."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Tan S.-H."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Tan S.-H."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Anan T."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/author | "Anan T."xsd:string |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17000875 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |