| http://purl.uniprot.org/citations/17003107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17003107 | http://www.w3.org/2000/01/rdf-schema#comment | "In S. cerevisiae synthesis of phosphatidylinositol (3,5)-bisphosphate [PtdIns(3,5)P2] by Fab1p is required for several cellular events, including an as yet undefined step in the ubiquitin-dependent trafficking of some integral membrane proteins from the trans-Golgi network to the vacuole lumen. AP-1 is a heterotetrameric clathrin adaptor protein complex that binds cargo proteins and clathrin coats, and regulates bi-directional protein trafficking between the trans-Golgi network and the endocytic/secretory pathway. Like fab1Delta cells, AP-1 complex component mutants have lost the ability to traffic ubiquitylated cargoes to the vacuole lumen - the first demonstration that AP-1 is required for this process. Deletion mutants of AP-1 complex components are compromised in their ability to synthesize PtdIns(3,5)P2, indicating that AP-1 is required for correct in vivo activation of Fab1p. Furthermore, wild-type protein sorting can be restored in AP-1 mutants by overexpression of Fab1p, implying that the protein-sorting defect in these cells is as a result of disruption of PtdIns(3,5)P2 synthesis. Finally, we show that Fab1p and Vac14p, an activator of Fab1p, are also required for another AP-1-dependent process: chitin-ring deposition in chs6Delta cells. Our data imply that AP-1 is required for some Fab1p and PtdIns(3,5)P2-dependent processes."xsd:string |
| http://purl.uniprot.org/citations/17003107 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.03188"xsd:string |
| http://purl.uniprot.org/citations/17003107 | http://purl.uniprot.org/core/author | "Parker P.J."xsd:string |
| http://purl.uniprot.org/citations/17003107 | http://purl.uniprot.org/core/author | "Piper P.W."xsd:string |
| http://purl.uniprot.org/citations/17003107 | http://purl.uniprot.org/core/author | "Phelan J.P."xsd:string |
| http://purl.uniprot.org/citations/17003107 | http://purl.uniprot.org/core/author | "Millson S.H."xsd:string |
| http://purl.uniprot.org/citations/17003107 | http://purl.uniprot.org/core/author | "Cooke F.T."xsd:string |
| http://purl.uniprot.org/citations/17003107 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17003107 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/17003107 | http://purl.uniprot.org/core/pages | "4225-4234"xsd:string |
| http://purl.uniprot.org/citations/17003107 | http://purl.uniprot.org/core/title | "Fab1p and AP-1 are required for trafficking of endogenously ubiquitylated cargoes to the vacuole lumen in S. cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/17003107 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/17003107 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17003107 |
| http://purl.uniprot.org/citations/17003107 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17003107 |
| http://purl.uniprot.org/uniprot/P35181#attribution-38DDB09DCB13A0758203C7C758E90ADF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17003107 |
| http://purl.uniprot.org/uniprot/P35181#attribution-4A880BFB45A9AE9A5557FD5A7D00D509 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17003107 |
| http://purl.uniprot.org/uniprot/Q12028#attribution-38DDB09DCB13A0758203C7C758E90ADF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17003107 |
| http://purl.uniprot.org/uniprot/Q12028#attribution-4A880BFB45A9AE9A5557FD5A7D00D509 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17003107 |
| http://purl.uniprot.org/uniprot/P36000#attribution-38DDB09DCB13A0758203C7C758E90ADF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17003107 |
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| http://purl.uniprot.org/uniprot/Q00776#attribution-C13C8E888B1469921E74010AAB3453D9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17003107 |