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http://purl.uniprot.org/citations/17003171http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17003171http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The aim of this study was to assess the potential contribution of HLA-class I MICA and HLA-B gene polymorphisms towards the pathogenesis of giant cell arteritis (GCA).

Methods

Ninety-eight biopsy-proven GCA patients and 225 ethnically matched controls from Lugo, Northwest Spain, were genotyped for the MICA-TM microsatellite polymorphism using a polymerase chain reaction (PCR)-based method. Genotyping of HLA-B was performed using PCR and detection with a reverse sequence-specific oligonucleotide (SSO) probes system.

Results

A significant difference in the distribution of the alleles of MICA between patient and control groups (P = 0.005) was found. This was due to an increased frequency of the MICA A5 allele in GCA patients compared with controls (26 vs 13.6%; P = 0.0001; P(C) = 0.0005; OR 2.2, 95% CI 1.4-3.4). In addition, the HLA-B*15 allele showed a higher frequency in GCA patients compared with controls (P = 0.004; P(C) = 0.04; OR 2.7, 95% CI 1.3-5.7). Interestingly, the association observed with the MICA A5 allele seems to be independent of linkage disequilibrium with HLA-B, as well as independent of that previously described with HLA-DRB1*04. Remarkably, simultaneous presence of MICA A5 and HLA-B*15 or HLA-DRB1*04 genetic markers leads to an increase in the OR obtained for each individual genetic marker (MICA A5 + B*15 OR 3.2; MICA A5 + DRB1*04 OR 5.8).

Conclusions

Our results provide the first evidence that the MICA and HLA-B genes are independently associated with the genetic susceptibility to GCA, and suggest that several genes within the MHC might have independent effects in the susceptibility to this systemic vasculitis."xsd:string
http://purl.uniprot.org/citations/17003171http://purl.org/dc/terms/identifier"doi:10.1093/rheumatology/kel324"xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/author"Martin J."xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/author"Gonzalez-Escribano M.F."xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/author"Gonzalez-Gay M.A."xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/author"Lopez-Nevot M.A."xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/author"Fernandez O."xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/author"Rueda B."xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/author"Robledo G."xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/author"Garcia-Porrua C."xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/author"Ruiz M.P."xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/author"Vilchez J.R."xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/name"Rheumatology (Oxford)"xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/pages"431-434"xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/title"Contribution of MHC class I region to genetic susceptibility for giant cell arteritis."xsd:string
http://purl.uniprot.org/citations/17003171http://purl.uniprot.org/core/volume"46"xsd:string
http://purl.uniprot.org/citations/17003171http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17003171
http://purl.uniprot.org/citations/17003171http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17003171
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-17003171http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17003171
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-17003171http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17003171
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-17003171http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17003171
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-17003171http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17003171
http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-17003171http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17003171
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