| http://purl.uniprot.org/citations/17003176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17003176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17003176 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectivesSeveral recent studies have shown that the MHC class III region, located telomeric to HLA-DRB1, contains an additional genetic factor that predisposes to rheumatoid arthritis (RA). In this study, we investigate whether inhibitor of kappaB-like (IkappaBL), MICB or MICA located in the MHC class III region are the second susceptibility gene associated with RA.MethodsA total of 154 healthy controls and 140 RA patients were genotyped for HLA-DRB1, MICA, MICB and the polymorphism -62 of the IkappaBL gene.ResultsA significant increase of HLA-DRB1 shared epitope (SE) alleles was detected in RA patients (61.4 vs 43.5%, P(c) = 0.01, OR = 2.1, 95% CI = 1.3-3.3). Among SE alleles, the HLA-DRB1*0401 (13.5 vs 5.1%, P(c) = 0.04, OR = 3.2, 95% CI = 1.3-8.1) and HLA-DRB1*0404 (6.4 vs 1.2%, P = 0.02, P(c) = NS) showed the most significantly association with RA. No increase of risk was associated with HLA-DRB1*01. Remarkably, the allele MICB*004 was also significantly associated with RA susceptibility (40.7 vs 23.3%, P(c) = 0.01, OR = 2.2, 95% CI = 1.3-3.7). MICB*004 was in linkage disequilibrium with HLA-DRB1*0404 (lambda(s) = 0.33) and HLA-DRB1*0405 (lambda(s) = 0.34). However, MICB*004 was also increased in HLA-DRB1 SE negative patients (37 vs 21.5%, P = 0.04). No significant association between IkappaBL and MICA with RA was found.ConclusionsMICB*004 allele was associated with RA susceptibility. This allele was in linkage disequilibrium with HLA-DRB1*0404 and DRB1*0405. The association of MICB with RA susceptibility and the functional role of MIC genes in the pathogenesis of RA converts MICB into a candidate to be an additional MHC gene associated with RA susceptibility."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.org/dc/terms/identifier | "doi:10.1093/rheumatology/kel331"xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.org/dc/terms/identifier | "doi:10.1093/rheumatology/kel331"xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Gonzalez S."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Gonzalez S."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Lopez-Larrea C."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Lopez-Larrea C."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Alperi-Lopez M."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Alperi-Lopez M."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Ballina-Garcia F.J."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Ballina-Garcia F.J."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Fernandez-Morera J.L."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Fernandez-Morera J.L."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Lopez-Arbesu R."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Lopez-Arbesu R."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Lopez-Soto A."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Lopez-Soto A."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Lopez-Vazquez A."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Lopez-Vazquez A."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Martinez-Borra J."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Martinez-Borra J."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Queiro-Silva R."xsd:string |
| http://purl.uniprot.org/citations/17003176 | http://purl.uniprot.org/core/author | "Queiro-Silva R."xsd:string |