DESCRIBE <http://purl.uniprot.org/citations/17003450>

Subject	Predicate	Object
http://purl.uniprot.org/citations/17003450	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17003450	http://www.w3.org/2000/01/rdf-schema#comment	" Purpose To assess changes in rod and cone visual functions in a mouse model of Fundus albipunctatus with disrupted 11-cis-retinol dehydrogenase (RDH) genes after pharmacologic treatment with an artificial retinal chromophore. Methods Retinoid levels and photoreceptor functions of Rdh5-/-Rdh11-/-mice at a variety of light intensities were analyzed with normal-phase HPLC and ERG techniques. Production of 11-cis-retinal, the visual pigment chromophore, was suppressed with a potent inhibitor of the retinoid cycle, all-trans-retinylamine (Ret-NH2). The chromophore was replaced by a functional geometric isomer, 9-cis-retinal, delivered by oral gavage. Results Aberrant cone responses were detected in 12-month-old Rdh5-/-Rdh11-/-mice raised in a 12-hour light/12-hour dark cycle. This cone defect was exacerbated in conditions of low levels of 11-cis-retinal. Administration of 9-cis-retinal increased the rate of dark adaptation and improved cone function in Rdh5-/-Rdh11-/-mice. Conclusions Disruption of 11-cis-RDHs causes a slowly developing cone dystrophy caused by inefficient cone pigment regeneration. Rod and cone visual function improved significantly in the mouse model of F. albipunctatus after treatment with 9-cis-retinal, suggesting a potential approach to slow the progression of cone dystrophy in affected humans."xsd:string
http://purl.uniprot.org/citations/17003450	http://purl.org/dc/terms/identifier	"doi:10.1167/iovs.06-0215"xsd:string
http://purl.uniprot.org/citations/17003450	http://purl.uniprot.org/core/author	"Maeda A."xsd:string
http://purl.uniprot.org/citations/17003450	http://purl.uniprot.org/core/author	"Maeda T."xsd:string
http://purl.uniprot.org/citations/17003450	http://purl.uniprot.org/core/author	"Palczewski K."xsd:string
http://purl.uniprot.org/citations/17003450	http://purl.uniprot.org/core/date	"2006"xsd:gYear
http://purl.uniprot.org/citations/17003450	http://purl.uniprot.org/core/name	"Invest Ophthalmol Vis Sci"xsd:string
http://purl.uniprot.org/citations/17003450	http://purl.uniprot.org/core/pages	"4540-4546"xsd:string
http://purl.uniprot.org/citations/17003450	http://purl.uniprot.org/core/title	"Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal."xsd:string
http://purl.uniprot.org/citations/17003450	http://purl.uniprot.org/core/volume	"47"xsd:string
http://purl.uniprot.org/citations/17003450	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/17003450
http://purl.uniprot.org/citations/17003450	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/17003450
http://purl.uniprot.org/uniprot/#_D3YWG0-mappedCitation-17003450	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17003450
http://purl.uniprot.org/uniprot/#_D3Z0N7-mappedCitation-17003450	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17003450
http://purl.uniprot.org/uniprot/#_E0CYX0-mappedCitation-17003450	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17003450
http://purl.uniprot.org/uniprot/#_D3YZQ7-mappedCitation-17003450	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17003450
http://purl.uniprot.org/uniprot/#_F7CWI9-mappedCitation-17003450	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17003450
http://purl.uniprot.org/uniprot/#_O55240-mappedCitation-17003450	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17003450
http://purl.uniprot.org/uniprot/#_Q8BSF7-mappedCitation-17003450	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17003450
http://purl.uniprot.org/uniprot/#_Q9QYF1-mappedCitation-17003450	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17003450
http://purl.uniprot.org/uniprot/#_Q9R1R8-mappedCitation-17003450	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17003450
http://purl.uniprot.org/uniprot/#_Q9R1R9-mappedCitation-17003450	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17003450
http://purl.uniprot.org/uniprot/F7CWI9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/17003450
http://purl.uniprot.org/uniprot/Q9QYF1	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/17003450