| http://purl.uniprot.org/citations/17004937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17004937 | http://www.w3.org/2000/01/rdf-schema#comment | "Cocaine addiction is an enduring, relapsing, behavioural disorder in which stressors reinstate cocaine-seeking even after prolonged abstinence. Evidence suggests that the 'anxiety-like' behaviour and stress associated with protracted withdrawal may be mediated by increased corticotropin-releasing factor (CRF) in the central nucleus of the amygdala (CeA), a part of the limbic circuitry engaged in the coding and transmission of stimulus-reward associations. In the present study we describe a long-lasting potentiation of glutamatergic transmission induced at lateral amygdala (LA)-to-CeA synapses by rat/human CRF. After 2 weeks of withdrawal from repeated intermittent exposure to cocaine, CRF-induced long-term potentiation (LTP) was greatly enhanced compared to the respective saline control group while, after short-term withdrawal (24 h), there was no significant difference between the two treatment groups, indicating alterations in CRF systems during protracted withdrawal from chronic cocaine. After prolonged withdrawal, CRF-induced LTP was dependent on activation of CRF2, CaV2.3 (R-type) calcium channels and intracellular signalling through protein kinase C in both saline- and cocaine-treated groups. The enhanced CRF-induced LTP after 2 weeks of withdrawal was mediated through augmented CRF1 receptor function, associated with an increased signalling through protein kinase A, and required N-methyl-D-aspartate (NMDA) receptors. Accordingly, single-cell recordings revealed a significantly increased NMDA/AMPA ratio after prolonged withdrawal from the cocaine treatment. These results support a role for CRF1 receptor antagonists as plausible treatment options during withdrawal from chronic cocaine and suggest Ca(V)2.3 blockers as potential candidates for pharmaceutical modulation of CRF systems."xsd:string |
| http://purl.uniprot.org/citations/17004937 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1460-9568.2006.05049.x"xsd:string |
| http://purl.uniprot.org/citations/17004937 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/17004937 | http://purl.uniprot.org/core/author | "Vale W.W."xsd:string |
| http://purl.uniprot.org/citations/17004937 | http://purl.uniprot.org/core/author | "Grigoriadis D.E."xsd:string |
| http://purl.uniprot.org/citations/17004937 | http://purl.uniprot.org/core/author | "Gallagher J.P."xsd:string |
| http://purl.uniprot.org/citations/17004937 | http://purl.uniprot.org/core/author | "Shinnick-Gallagher P."xsd:string |
| http://purl.uniprot.org/citations/17004937 | http://purl.uniprot.org/core/author | "Orozco-Cabal L."xsd:string |
| http://purl.uniprot.org/citations/17004937 | http://purl.uniprot.org/core/author | "Pollandt S."xsd:string |
| http://purl.uniprot.org/citations/17004937 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17004937 | http://purl.uniprot.org/core/name | "Eur J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17004937 | http://purl.uniprot.org/core/pages | "1733-1743"xsd:string |
| http://purl.uniprot.org/citations/17004937 | http://purl.uniprot.org/core/title | "Cocaine withdrawal enhances long-term potentiation induced by corticotropin-releasing factor at central amygdala glutamatergic synapses via CRF, NMDA receptors and PKA."xsd:string |
| http://purl.uniprot.org/citations/17004937 | http://purl.uniprot.org/core/volume | "24"xsd:string |
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