| http://purl.uniprot.org/citations/17005282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17005282 | http://www.w3.org/2000/01/rdf-schema#comment | "The functions of fukutin, a gene product responsible for Fukuyama type congenital muscular dystrophy, still remain unclear, although a relation to the glycosylation of alpha-dystroglycan is presumed. To investigate the functions of fukutin, immunohistochemistry, examination using cultured astrocytes, enzyme-linked immunosorbent assay (ELISA)-based binding assay and immunoprecipitation were performed using control muscle and central nervous system tissues. Immunohistochemistry showed that alpha-dystroglycan and fukutin were co-expressed, especially in the glial cytoplasm and glia limitans of the central nervous system. An anti-fukutin antibody added to the culture medium did not bring about any changes in the astrocytes cultured on laminin-coated dishes. Together with the immunohistochemical results, the intracellular function of fukutin is considered. ELISA-based binding assay and immunoprecipitation may suggest the direct binding of fukutin and alpha-dystroglycan, at least in part. Fukutin seems to bind to both the hypoglycosylated and fully glycosylated form of alpha-dystroglycan, and seems bind to the core area rather than the sugar chain of alpha-dystroglycan. Fukutin may directly interact with alpha-dystroglycan during glycosylation, but further examinations are needed to confirm these details."xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neures.2006.08.009"xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://purl.uniprot.org/core/author | "Kobayashi M."xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://purl.uniprot.org/core/author | "Kato Y."xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://purl.uniprot.org/core/author | "Kawaguchi M."xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://purl.uniprot.org/core/author | "Shibata N."xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://purl.uniprot.org/core/author | "Morikawa S."xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://purl.uniprot.org/core/author | "Muramatsu F."xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://purl.uniprot.org/core/author | "Sakayori N."xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17005282 | http://purl.uniprot.org/core/name | "Neurosci Res"xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://purl.uniprot.org/core/pages | "391-399"xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://purl.uniprot.org/core/title | "Intracellular binding of fukutin and alpha-dystroglycan: relation to glycosylation of alpha-dystroglycan."xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/17005282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17005282 |
| http://purl.uniprot.org/citations/17005282 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17005282 |
| http://purl.uniprot.org/uniprot/#_Q14118-mappedCitation-17005282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17005282 |
| http://purl.uniprot.org/uniprot/#_A0A1B1PFW2-mappedCitation-17005282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17005282 |
| http://purl.uniprot.org/uniprot/#_B4DN78-mappedCitation-17005282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17005282 |
| http://purl.uniprot.org/uniprot/#_B4E2W4-mappedCitation-17005282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17005282 |
| http://purl.uniprot.org/uniprot/#_G3XFS1-mappedCitation-17005282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17005282 |
| http://purl.uniprot.org/uniprot/#_I6L9J5-mappedCitation-17005282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17005282 |
| http://purl.uniprot.org/uniprot/#_O75072-mappedCitation-17005282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17005282 |