| http://purl.uniprot.org/citations/17006958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17006958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17006958 | http://www.w3.org/2000/01/rdf-schema#comment | "The study of MS-KIF18A kinesin protein is focused on its cellular distribution and association with a cargo protein. Indirect immunofluorescence (IF) analyzed the intracellular distribution of endogenous MS-KIF18A and the transfected enhanced green fluorescence protein (eGFP)-MS-KIF18A in osteogenic cells. In both cases, the proteins were localized at the plasma membrane, cytosol, and nucleus. Bioinformatics analysis suggested interactions between MS-KIF18A and estrogen receptor (ERalpha) which were further elucidated by immunoprecipitation (IP). We identified interaction between endogenous MS-KIF18A with 66 and 46 kDa isoforms of ERalpha in MBA-15 cells. Moreover, MS-KIF18A and 66 kDa ERalpha complex has been demonstrated between ectopically expressed proteins in COS-7 cells. We have shown that anti-MS-KIF18A antibody immunoprecipitated the ERalpha and pERK in cells challenged with 17beta-estrogen (17beta-E2). The hormone activation induced mitogen-activated protein kinases (MAPK) pathway and increased p-ERK. The activation was interfered when cells were pre-treated with either ICI-182,780 or MAPK inhibitor PD98059 prior the challenge with 17beta-E2 that resulted in a decrease in association between MS-KIF18A and p-ERK1/2. The obtained results suggest a role for the proteins in a non-genomic response of MBA-15 cells challenged with 17beta-E2. This study presents a novel interaction between MS-KIF18A and ER that may have important physiological and pharmacological implications for estrogen action in various cells."xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.21000"xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.21000"xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/author | "Benayahu D."xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/author | "Benayahu D."xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/author | "Luboshits G."xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/author | "Luboshits G."xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/pages | "693-702"xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/pages | "693-702"xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/title | "MS-KIF18A, a kinesin, is associated with estrogen receptor."xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/title | "MS-KIF18A, a kinesin, is associated with estrogen receptor."xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/17006958 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17006958 |
| http://purl.uniprot.org/citations/17006958 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17006958 |
| http://purl.uniprot.org/citations/17006958 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17006958 |
| http://purl.uniprot.org/citations/17006958 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17006958 |
| http://purl.uniprot.org/uniprot/P03372 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17006958 |
| http://purl.uniprot.org/uniprot/Q8NI77 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17006958 |