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http://purl.uniprot.org/citations/17007737http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17007737http://www.w3.org/2000/01/rdf-schema#comment"

Aim

To observe the effects of sodium ferulate (SF) on amyloid beta (Abeta)1-40-induced p38 mitogen-activated protein kinase (MAPK) signal transduction pathway and the neuroprotective effects of SF.

Methods

Rats were injected intracerebroventricularly with Abeta1-40. Six hours after injection, Western blotting was used to determine the expressions of phosphorylated mitogen-activated protein kinase kinase (MKK) 3/MKK6, phospho-p38 MAPK, interleukin (IL)-1beta, phospho-MAPK activating protein kinase 2 (MAPKAPK-2), the 27 kDa heat shock protein (Hsp27), procaspase-9, -3, and -7 cleavage, and poly (ADP-ribose) polymerase (PARP) cleavage. Seven days after injection, Nissl staining was used to observe the morphological change in hippocampal CA1 regions.

Results

Intracerebroventricular injection of Abeta1-40 induced an increase in phosphorylated MKK3/MKK6 and p38 MAPK expressions in hippocampal tissue. These increases, in combination with enhanced interleukin (IL)-1beta protein expression and reduced phospho-MAPKAPK2 and phospho-Hsp27 expression, mediate the Abeta-induced activation of cell death events as assessed by cleavage of procaspase-9, -3, and -7 and caspase-3 substrate PARP cleavage. Pretreatment with SF (100 mg/kg and 200 mg/kg daily, 3 weeks) significantly prevented Abeta1-40-induced increases in phosphorylated MKK3/MKK6 and p38 MAPK expression. The Abeta1-40-induced increase in IL-1beta protein level was attenuated by pretreatment with SF. In addition, Abeta1-40-induced decreases in phosphorylated MAPKAPK2 and Hsp27 expression were abrogated by administration of SF. In parallel with these findings, Abeta1-40-induced changes in activation of caspase-9, caspase-7, and caspase-3 were inhibited by pretreatment with SF.

Conclusion

SF prevents Abeta1-40-induced neurotoxicity through suppression of MKK3/MKK6-p38 MAPK activity and IL-1beta expression and upregulation of phospho-Hsp27 expression."xsd:string
http://purl.uniprot.org/citations/17007737http://purl.org/dc/terms/identifier"doi:10.1111/j.1745-7254.2006.00414.x"xsd:string
http://purl.uniprot.org/citations/17007737http://purl.uniprot.org/core/author"Fan Y."xsd:string
http://purl.uniprot.org/citations/17007737http://purl.uniprot.org/core/author"Jin Y."xsd:string
http://purl.uniprot.org/citations/17007737http://purl.uniprot.org/core/author"Liu Z."xsd:string
http://purl.uniprot.org/citations/17007737http://purl.uniprot.org/core/author"Qi Z.M."xsd:string
http://purl.uniprot.org/citations/17007737http://purl.uniprot.org/core/author"Yan E.Z."xsd:string
http://purl.uniprot.org/citations/17007737http://purl.uniprot.org/core/author"Zong Z.H."xsd:string
http://purl.uniprot.org/citations/17007737http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/17007737http://purl.uniprot.org/core/name"Acta Pharmacol Sin"xsd:string
http://purl.uniprot.org/citations/17007737http://purl.uniprot.org/core/pages"1309-1316"xsd:string
http://purl.uniprot.org/citations/17007737http://purl.uniprot.org/core/title"Effects of sodium ferulate on amyloid-beta-induced MKK3/MKK6-p38 MAPK-Hsp27 signal pathway and apoptosis in rat hippocampus."xsd:string
http://purl.uniprot.org/citations/17007737http://purl.uniprot.org/core/volume"27"xsd:string
http://purl.uniprot.org/citations/17007737http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17007737
http://purl.uniprot.org/citations/17007737http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17007737
http://purl.uniprot.org/uniprot/#_Q925D6-mappedCitation-17007737http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17007737
http://purl.uniprot.org/uniprot/Q925D6http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17007737