| http://purl.uniprot.org/citations/17009320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17009320 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17009320 | http://www.w3.org/2000/01/rdf-schema#comment | "The cdk5/p35 complex has been implicated in a variety of functions related to brain development, including axonal outgrown and neuronal migration. In this study, by co-immunoprecipitation and pull-down experiments, we have shown that the cdk5/p35 complex associates with and phosphorylates the neuronal delta-catenin. Immunocytochemical studies of delta-catenin and the cdk5-activator p35 in primary cortical neurons indicated that these proteins co-localize in the cell body of neuronal cells. In addition, cdk5 co-localized with beta-catenin in the cell-cell contacts and plasma membrane of undifferentiated and differentiated N2A cells. In this context, we identified Ser(191) and Ser(246) on beta-catenin structure as specific phosphorylation sites for cdk5/p35 complex. Moreover, Pin1, a peptidyl-prolyl isomerase (PPIase) directly bound to both, beta- and delta-catenin, once they have been phosphorylated by the cdk5/p35 complex. Studies indicate that the cdk5/p35 protein kinase system is directly involved in the regulatory mechanisms of neuronal beta- and delta-catenin."xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.21041"xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.21041"xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/author | "Huichalaf C.H."xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/author | "Huichalaf C.H."xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/author | "Maccioni R.B."xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/author | "Maccioni R.B."xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/author | "Munoz J.P."xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/author | "Munoz J.P."xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/author | "Orellana D."xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/author | "Orellana D."xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/name | "J. Cell. Biochem."xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/pages | "738-749"xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/pages | "738-749"xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/title | "cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells."xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/title | "cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells."xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/17009320 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17009320 |
| http://purl.uniprot.org/citations/17009320 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17009320 |