| http://purl.uniprot.org/citations/17011187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17011187 | http://www.w3.org/2000/01/rdf-schema#comment | "An N-formamido pyrrole- and imidazole-containing triamide (f-PIP) has been shown by DNase I footprinting, SPR, and CD studies to bind as a stacked dimer to its cognate sequences: 5'-TACGAT-3' (5'-flank of the inverted CCAAT box-2 of the human topoisomerase IIalpha promoter) and 5'-ATCGAT-3'. A gel shift experiment provided evidence for f-PIP to inhibit protein-DNA interaction at the ICB2 site. Western blot studies showed that expression of the topoisomerase IIalpha gene in confluent NIH 3T3 cells was induced by treatment with f-PIP. The results suggested that the triamide was able to enter the nucleus, interacted with the target site within ICB2, inhibited NF-Y binding, and activated gene expression."xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bmcl.2006.09.043"xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/author | "Brown T."xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/author | "Lee M."xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/author | "Cooper A.J."xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/author | "Hartley J.A."xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/author | "O'Hare C."xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/author | "Le N.M."xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/author | "Hochhauser D."xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/author | "Kotecha M."xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/author | "Mackay H."xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/author | "Sielaff A.M."xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/name | "Bioorg Med Chem Lett"xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/pages | "6161-6164"xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/title | "Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIalpha promoter and modulation of gene expression in cells."xsd:string |
| http://purl.uniprot.org/citations/17011187 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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