| http://purl.uniprot.org/citations/17013982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17013982 | http://www.w3.org/2000/01/rdf-schema#comment | "Thy-1 (CD90) is a glycoprotein bound to the plasma membrane by a GPI anchor. Aggregation of Thy-1 in mast cells and basophils induces activation events independent of the expression of Fcepsilon receptor I (FcepsilonRI). Although we and others have previously suggested that plasma membrane microdomains called lipid rafts are implicated in both Thy-1 and FcepsilonRI signaling, properties of these microdomains are still poorly understood. In this study we used rat basophilic leukemia cells and their transfectants expressing both endogenous Thy-1.1 and exogenous Thy-1.2 genes and analyzed topography of the Thy-1 isoforms and Thy-1-induced signaling events. Light microscopy showed that both Thy-1 isoforms were in the plasma membrane distributed randomly and independently. Electron microscopy on isolated membrane sheets and fluorescence resonance energy transfer analysis indicated cross-talk between Thy-1 isoforms and between Thy-1 and FcepsilonRI. This cross-talk was dependent on actin filaments. Thy-1 aggregates colocalized with two transmembrane adaptor proteins, non-T cell activation linker (NTAL) and linker for activation of T cells (LAT), which had been shown to inhabit different membrane microdomains. Thy-1 aggregation led to tyrosine phosphorylation of these two adaptors. The combined data indicate that aggregated GPI-anchored proteins can attract different membrane proteins in different clusters and thus can trigger different signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/17013982 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200636159"xsd:string |
| http://purl.uniprot.org/citations/17013982 | http://purl.uniprot.org/core/author | "Draber P."xsd:string |
| http://purl.uniprot.org/citations/17013982 | http://purl.uniprot.org/core/author | "Heneberg P."xsd:string |
| http://purl.uniprot.org/citations/17013982 | http://purl.uniprot.org/core/author | "Lebduska P."xsd:string |
| http://purl.uniprot.org/citations/17013982 | http://purl.uniprot.org/core/author | "Draberova L."xsd:string |
| http://purl.uniprot.org/citations/17013982 | http://purl.uniprot.org/core/author | "Korb J."xsd:string |
| http://purl.uniprot.org/citations/17013982 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17013982 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17013982 | http://purl.uniprot.org/core/pages | "2795-2806"xsd:string |
| http://purl.uniprot.org/citations/17013982 | http://purl.uniprot.org/core/title | "Topography of plasma membrane microdomains and its consequences for mast cell signaling."xsd:string |
| http://purl.uniprot.org/citations/17013982 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/17013982 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17013982 |
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