| http://purl.uniprot.org/citations/17015685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17015685 | http://www.w3.org/2000/01/rdf-schema#comment | "Vav proteins play a critical role in T cell activation and proliferation by promoting cytoskeleton reorganization, transcription factor activation, and cytokine production. In this study, we investigated the role of Vav in T cell cycle progression. TCR/CD28-stimulated Vav1(-/-) T cells displayed a cell cycle block at the G0-G1 stage, which accounted for their defective proliferation. This defect was associated with impaired TCR/CD28-induced phosphorylation of Akt and the Forkhead family transcription factor, FOXO1. The cytoplasmic localization of FOXO1 and its association with 14-3-3tau were also reduced in Vav1(-/-) T cells. Consistent with the important role of FOXO1 in p27 kip1 transcription, stimulated Vav1(-/-) T cells failed to down-regulate the expression of p27 kip1, explaining their G0-G1 arrest. These defects were more pronounced in Vav1/Vav3 double-deficient T cells, suggesting partial redundancy between Vav1 and Vav3. Importantly, IL-2-induced p27 kip1 down-regulation and cyclin D3 up-regulation and FOXO1 phosphorylation were similar in Vav1(-/-) and wild-type T lymphoblasts, indicating that defective FOXO1 phosphorylation and p27 kip1 and cyclin D3 expression do not result from deficient IL-2 signaling in the absence of Vav1. Thus, Vav1 is a critical regulator of a PI3K/Akt/FOXO1 pathway, which controls T cell cycle progression and proliferation."xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.8.5024"xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://purl.uniprot.org/core/author | "Swat W."xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://purl.uniprot.org/core/author | "Charvet C."xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://purl.uniprot.org/core/author | "Maurer U."xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://purl.uniprot.org/core/author | "Altman A."xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://purl.uniprot.org/core/author | "Deckert M."xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://purl.uniprot.org/core/author | "Miletic A.V."xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://purl.uniprot.org/core/author | "Canonigo A.J."xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://purl.uniprot.org/core/author | "Becart S."xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17015685 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://purl.uniprot.org/core/pages | "5024-5031"xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://purl.uniprot.org/core/title | "Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression."xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/17015685 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17015685 |
| http://purl.uniprot.org/citations/17015685 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17015685 |
| http://purl.uniprot.org/uniprot/#_E9PXI0-mappedCitation-17015685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17015685 |
| http://purl.uniprot.org/uniprot/#_O08525-mappedCitation-17015685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17015685 |
| http://purl.uniprot.org/uniprot/#_O08526-mappedCitation-17015685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17015685 |
| http://purl.uniprot.org/uniprot/#_Q3V0U7-mappedCitation-17015685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17015685 |
| http://purl.uniprot.org/uniprot/#_Q3TXC4-mappedCitation-17015685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17015685 |
| http://purl.uniprot.org/uniprot/#_Q3U8U1-mappedCitation-17015685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17015685 |
| http://purl.uniprot.org/uniprot/#_Q3U9E2-mappedCitation-17015685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17015685 |