| http://purl.uniprot.org/citations/17015726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17015726 | http://www.w3.org/2000/01/rdf-schema#comment | "Functional peripheral mature follicular B (FoB) lymphocytes are thought to develop from immature transitional cells in a BCR-dependent manner. We have previously shown that BCR cross-linking in vitro results in death of early transitional (T1) B cells, whereas late transitional (T2) B cells survive and display phenotypic characteristics of mature FoB cells. We now demonstrate that diacylglycerol (DAG), a lipid second messenger implicated in cell survival and differentiation, is produced preferentially in T2 compared with T1 B cells upon BCR cross-linking. Consistently, inositol 1,4,5-triphosphate is also produced preferentially in T2 compared with T1 B cells. Unexpectedly, the initial calcium peak appears similar in both T1 and T2 B cells, whereas sustained calcium levels are higher in T1 B cells. Pretreatment with 2-aminoethoxydiphenylborate, an inhibitor of inositol 1,4,5-triphosphate receptor-mediated calcium release, and verapamil, an inhibitor of L-type calcium channels, preferentially affects T1 B cells, suggesting that distinct mechanisms regulate calcium mobilization in each of the two transitional B cell subsets. Finally, BCR-mediated DAG production is dependent upon Bruton's tyrosine kinase and phospholipase C-gamma2, enzymes required for the development of FoB from T2 B cells. These results suggest that calcium signaling in the absence of DAG-mediated signals may lead to T1 B cell tolerance, whereas the combined action of DAG and calcium signaling is necessary for survival and differentiation of T2 into mature FoB lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.177.8.5405"xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/author | "Lowe J."xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/author | "Wente S.R."xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/author | "Khan W.N."xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/author | "Gerstein R.M."xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/author | "Sarmah B."xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/author | "Antony P."xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/author | "Hoek K.L."xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/author | "Shinners N."xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/pages | "5405-5413"xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/title | "Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement."xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/17015726 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17015726 |
| http://purl.uniprot.org/citations/17015726 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17015726 |
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| http://purl.uniprot.org/uniprot/#_P35991-mappedCitation-17015726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17015726 |
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| http://purl.uniprot.org/uniprot/#_Q8CIH5-mappedCitation-17015726 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17015726 |
| http://purl.uniprot.org/uniprot/P35991 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17015726 |
| http://purl.uniprot.org/uniprot/Q7TMU1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17015726 |