| http://purl.uniprot.org/citations/17015829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17015829 | http://www.w3.org/2000/01/rdf-schema#comment | "The homeobox transcription factors Engrailed-1 and Engrailed-2 are required for the survival of mesencephalic dopaminergic neurons in a cell-autonomous and gene-dose-dependent manner. Because of this requirement, the cells die by apoptosis when all four alleles of the Engrailed genes are genetically ablated (En1-/-;En2-/-). In the present study, we show that viable and fertile mice, heterozygous null for Engrailed-1 and homozygous null for Engrailed-2 (En1+/-;En2-/-), have an adult phenotype that resembles key pathological features of Parkinson's disease. Specifically, postnatal mutant mice exhibit a progressive degeneration of dopaminergic neurons in the substantia nigra during the first 3 mo of their lives, leading to diminished storage and release of dopamine in the caudate putamen, motor deficits similar to akinesia and bradykinesia, and a lower body weight. This genetic model may provide access to the molecular etiology for Parkinson's disease and could assist in the development of novel treatments for this neurodegenerative disorder."xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0602116103"xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/author | "Alavian K.N."xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/author | "Smidt M.P."xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/author | "Simon H.H."xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/author | "Ramakers G.M."xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/author | "Dyck R.H."xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/author | "Alberi L."xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/author | "Sgado P."xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/author | "Galasso S.L."xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/author | "Gherbassi D."xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/pages | "15242-15247"xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/title | "Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice."xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/17015829 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17015829 |
| http://purl.uniprot.org/citations/17015829 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17015829 |
| http://purl.uniprot.org/uniprot/#_P09065-mappedCitation-17015829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17015829 |
| http://purl.uniprot.org/uniprot/#_P09066-mappedCitation-17015829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17015829 |
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| http://purl.uniprot.org/uniprot/#_Q3USA2-mappedCitation-17015829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17015829 |
| http://purl.uniprot.org/uniprot/P09065 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17015829 |
| http://purl.uniprot.org/uniprot/Q3USA2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17015829 |