| http://purl.uniprot.org/citations/17018282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17018282 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear p68 RNA helicase (referred to as p68) is a prototypical member of the DEAD box family of RNA helicases. The protein plays a very important role in early organ development. In the present study, we characterized the tyrosine phosphorylation of p68 under platelet-derived growth factor (PDGF) stimulation. We demonstrated that tyrosine phosphorylation of p68 at Y593 mediated PDGF-stimulated epithelial-mesenchymal transition (EMT). We showed that PDGF treatment led to phosphorylation of p68 at Y593 in the cell nucleus. The Y593-phosphorylated p68 (referred to as phosphor-p68) promotes beta-catenin nuclear translocation via a Wnt-independent pathway. The phosphor-p68 facilitates beta-catenin nuclear translocation by blocking phosphorylation of beta-catenin by GSK-3beta and displacing Axin from beta-catenin. The beta-catenin nuclear translocation and subsequent interaction with the LEF/TCF was required for the EMT process. These data demonstrated a novel mechanism of phosphor-p68 in mediating the growth factor-induced EMT and uncovered a new pathway to promote beta-catenin nuclear translocation."xsd:string |
| http://purl.uniprot.org/citations/17018282 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2006.08.036"xsd:string |
| http://purl.uniprot.org/citations/17018282 | http://purl.uniprot.org/core/author | "Lin C."xsd:string |
| http://purl.uniprot.org/citations/17018282 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/17018282 | http://purl.uniprot.org/core/author | "Liu Z.R."xsd:string |
| http://purl.uniprot.org/citations/17018282 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17018282 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17018282 | http://purl.uniprot.org/core/pages | "139-155"xsd:string |
| http://purl.uniprot.org/citations/17018282 | http://purl.uniprot.org/core/title | "P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin."xsd:string |
| http://purl.uniprot.org/citations/17018282 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/17018282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17018282 |
| http://purl.uniprot.org/citations/17018282 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17018282 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4R0-mappedCitation-17018282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17018282 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4S3-mappedCitation-17018282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17018282 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4M1-mappedCitation-17018282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17018282 |
| http://purl.uniprot.org/uniprot/#_B4DSW9-mappedCitation-17018282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17018282 |
| http://purl.uniprot.org/uniprot/#_B2ZRE2-mappedCitation-17018282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17018282 |
| http://purl.uniprot.org/uniprot/#_B2ZRG2-mappedCitation-17018282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17018282 |
| http://purl.uniprot.org/uniprot/#_B4DGU4-mappedCitation-17018282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17018282 |
| http://purl.uniprot.org/uniprot/#_B4DL06-mappedCitation-17018282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17018282 |
| http://purl.uniprot.org/uniprot/#_B4DNG2-mappedCitation-17018282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17018282 |
| http://purl.uniprot.org/uniprot/#_B4DN41-mappedCitation-17018282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17018282 |
| http://purl.uniprot.org/uniprot/#_B1AH42-mappedCitation-17018282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17018282 |
| http://purl.uniprot.org/uniprot/#_B5BUE6-mappedCitation-17018282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17018282 |