http://purl.uniprot.org/citations/17020971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/17020971 | http://www.w3.org/2000/01/rdf-schema#comment | "PurposeB-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of monoclonal mature B cells. The G protein Galphas subunit has been linked to proapoptotic processes in cancer cell lines. The TT genotype of the GNAS1 T393C polymorphism is associated with increased Galphas transcript levels and a more favorable clinical course in different solid cancers.Experimental designWe retrospectively genotyped 144 patients with B-CLL to examine a potential association between T393C genotypes with progression-free survival (time from diagnosis to initiation of chemotherapy) and overall survival.ResultsThe C-allele frequency in the patient group was 0.57 and not significantly different from that of healthy blood donors. Median progression-free survival was significantly different between genotypes (TT 130 months; TC 100 months; CC 31 months; P = 0.0066). Multivariable analysis showed that besides of ZAP-70 (P = 0.005) and Binet stage (P < 0.001), the T393C polymorphism was an independent prognostic factor for progression-free survival [hazard ratio (HR) CC versus TT 2.7; P = 0.010]. In Binet A stages, ZAP-70-positive patients with CC genotypes had a HR of 4.4 to receive first therapy compared with ZAP-70-negative patients with T-alleles (P = 0.0001). Regarding overall survival, CC genotypes (median overall survival, 197 months) were at highest risk for death compared with T-alleles (median overall survival, 310 months) in both univariate (HR, 4.8; P < 0.0001) and multivariable analysis (HR, 5.6; P = 0.002).ConclusionsHere, we show that the GNAS1 T393C status is a novel independent prognostic marker in patients with B-CLL. These results could help to define patients who could benefit from an early individualized therapy."xsd:string |
http://purl.uniprot.org/citations/17020971 | http://purl.org/dc/terms/identifier | "doi:10.1158/1078-0432.ccr-06-0288"xsd:string |
http://purl.uniprot.org/citations/17020971 | http://purl.uniprot.org/core/author | "Siffert W."xsd:string |
http://purl.uniprot.org/citations/17020971 | http://purl.uniprot.org/core/author | "Kuppers R."xsd:string |
http://purl.uniprot.org/citations/17020971 | http://purl.uniprot.org/core/author | "Duhrsen U."xsd:string |
http://purl.uniprot.org/citations/17020971 | http://purl.uniprot.org/core/author | "Durig J."xsd:string |
http://purl.uniprot.org/citations/17020971 | http://purl.uniprot.org/core/author | "Frey U.H."xsd:string |
http://purl.uniprot.org/citations/17020971 | http://purl.uniprot.org/core/author | "Nuckel H."xsd:string |
http://purl.uniprot.org/citations/17020971 | http://purl.uniprot.org/core/author | "Sellmann L."xsd:string |
http://purl.uniprot.org/citations/17020971 | http://purl.uniprot.org/core/author | "Siemer D."xsd:string |
http://purl.uniprot.org/citations/17020971 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
http://purl.uniprot.org/citations/17020971 | http://purl.uniprot.org/core/name | "Clin Cancer Res"xsd:string |
http://purl.uniprot.org/citations/17020971 | http://purl.uniprot.org/core/pages | "5686-5692"xsd:string |
http://purl.uniprot.org/citations/17020971 | http://purl.uniprot.org/core/title | "The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia."xsd:string |
http://purl.uniprot.org/citations/17020971 | http://purl.uniprot.org/core/volume | "12"xsd:string |
http://purl.uniprot.org/citations/17020971 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17020971 |
http://purl.uniprot.org/citations/17020971 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17020971 |
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