| http://purl.uniprot.org/citations/17022943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17022943 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of adrenomedullin (AM), a potent vasodilator peptide, was studied during adipocyte differentiation of human mesenchymal stem cells (hMSCs). Immunoreactive AM levels in the medium were increased at day 4 and 8 of the adipocyte differentiation. Northern blot analysis showed increased expression of AM mRNA in hMSCs-derived adipocytes at day 4, 8, 12, and 18. Transient transfection assay showed that the promoter activity was higher in hMSCs-derived adipocytes than in hMSCs, when cells were transfected with plasmids containing a cis-acting region (-70/-29) of the human AM gene. Electrophoretic mobility shift assay showed that specific bands bound to the region (-70/-29) in hMSCs-derived adipocytes but not in hMSCs, and were abolished by the stimulatory protein 1 (Sp1) antibody. The present study has shown that AM expression is up-regulated during adipocyte differentiation of hMSCs probably via the interaction between Sp1 or Sp1-related factor(s) and the AM promoter region (-70/-29)."xsd:string |
| http://purl.uniprot.org/citations/17022943 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.09.089"xsd:string |
| http://purl.uniprot.org/citations/17022943 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/17022943 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/17022943 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/17022943 | http://purl.uniprot.org/core/author | "Shibahara S."xsd:string |
| http://purl.uniprot.org/citations/17022943 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17022943 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17022943 | http://purl.uniprot.org/core/pages | "616-622"xsd:string |
| http://purl.uniprot.org/citations/17022943 | http://purl.uniprot.org/core/title | "Adrenomedullin in adipocyte differentiation of human mesenchymal stem cells."xsd:string |
| http://purl.uniprot.org/citations/17022943 | http://purl.uniprot.org/core/volume | "350"xsd:string |
| http://purl.uniprot.org/citations/17022943 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17022943 |
| http://purl.uniprot.org/citations/17022943 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17022943 |
| http://purl.uniprot.org/uniprot/#_P35318-mappedCitation-17022943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17022943 |
| http://purl.uniprot.org/uniprot/P35318 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17022943 |