| http://purl.uniprot.org/citations/17023265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17023265 | http://www.w3.org/2000/01/rdf-schema#comment | "Superoxide anions react with nitric oxide to form peroxynitrite and hence reduce the bioavailability of nitric oxide in the arteries. Extracellular superoxide dismutase (EC-SOD) is a major superoxide scavenger in human plasma and vascular tissues. The objective of this study is to assess whether essential hypertension is associated with an alteration in EC-SOD activity. In this report, blood samples were obtained from hypertensive (n=39) and normotensive (n=37) African-Americans. Plasma EC-SOD activity was measured using in-gel activity staining and spectrophotometric assays, EC-SOD protein level was measured using Western blotting, nitrotyrosine was measured using slot blotting, 8-isoprostane was measured with an enzyme immunoassay, and plasma copper and zinc concentrations were measured using an atomic absorption assay. Our data demonstrate that the copper, zinc, and plasma EC-SOD protein concentrations in the hypertensive and normotensive subjects are indistinguishable. Compared to normotensive controls, hypertensive patients have significantly reduced plasma EC-SOD activity. Plasma nitrotyrosine and 8-isoprostane levels are significantly higher in the hypertensive patients than in normotensive controls. Results from this study suggest that a reduction in EC-SOD activity in hypertensive patients is not due to a down-regulation of the SOD3 gene (encoding EC-SOD) or deficiency in mineral cofactors. Furthermore, the reduced EC-SOD activity might be at least partially responsible for the increased oxidative stress, as reflected by increased plasma nitrotyrosine and 8-isoprostane, in hypertensive subjects."xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.freeradbiomed.2006.07.019"xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/author | "Guo Z."xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/author | "Ross J."xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/author | "Xiang W."xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/author | "Potts J."xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/author | "Sharan C."xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/author | "Floyd M."xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/author | "Nyanda A.M."xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/name | "Free Radic Biol Med"xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/pages | "1384-1391"xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/title | "Reduction in extracellular superoxide dismutase activity in African-American patients with hypertension."xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/17023265 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17023265 |
| http://purl.uniprot.org/citations/17023265 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17023265 |
| http://purl.uniprot.org/uniprot/#_A0A140VJU8-mappedCitation-17023265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17023265 |
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| http://purl.uniprot.org/uniprot/#_P08294-mappedCitation-17023265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17023265 |
| http://purl.uniprot.org/uniprot/#_Q16867-mappedCitation-17023265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17023265 |
| http://purl.uniprot.org/uniprot/Q16867 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17023265 |
| http://purl.uniprot.org/uniprot/A0A140VJU8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17023265 |