| http://purl.uniprot.org/citations/17023586 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17023586 | http://www.w3.org/2000/01/rdf-schema#comment | "B-1b cells produce IgM natural antibodies against alpha1-3Galbeta1-4GlcNAc (alphaGal). These can be tolerized by nonmyeloablative induction of mixed chimerism using alphaGal-positive (alphaGal+) donor marrow. We assessed the role of CR1/2 in this model for induction of tolerance of B-1b cells. Mixed hematopoietic chimerism was induced in alpha1-3galactosyltransferase (GalT-/-) and GalT-/-Cr2-/-mice with alphaGal+ BALB/c marrow donors. Anti-alphaGal Ab and anti-alphaGal Ab-producing B cells became undetectable in GalT-/-chimeras, whereas they persisted in chimeric GalT-/-Cr2-/-mice. To determine whether CR1/2 expression on stromal cells and/or hematopoietic cells was critical for B-1-cell tolerance, we generated GalT-/-radiation chimeras in which CR1/CR2 was expressed on either stromal cells, hematopoietic cells, neither, or both. After induction of mixed chimerism from alphaGal+ allogeneic bone marrow (BM) donors, anti-alphaGal-producing B cells were rendered tolerant in reconstituted recipients expressing only stromal CR1/CR2. Our results suggest a possible role for follicular dendritic cells that pick up immune complexes via CR1/CR2 receptors in the tolerization of B-1b cells."xsd:string |
| http://purl.uniprot.org/citations/17023586 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-02-002386"xsd:string |
| http://purl.uniprot.org/citations/17023586 | http://purl.uniprot.org/core/author | "Kawahara T."xsd:string |
| http://purl.uniprot.org/citations/17023586 | http://purl.uniprot.org/core/author | "Haspot F."xsd:string |
| http://purl.uniprot.org/citations/17023586 | http://purl.uniprot.org/core/author | "Carroll M.C."xsd:string |
| http://purl.uniprot.org/citations/17023586 | http://purl.uniprot.org/core/author | "Bardwell P.D."xsd:string |
| http://purl.uniprot.org/citations/17023586 | http://purl.uniprot.org/core/author | "Shimizu I."xsd:string |
| http://purl.uniprot.org/citations/17023586 | http://purl.uniprot.org/core/author | "Sykes M."xsd:string |
| http://purl.uniprot.org/citations/17023586 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17023586 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17023586 | http://purl.uniprot.org/core/pages | "1773-1781"xsd:string |
| http://purl.uniprot.org/citations/17023586 | http://purl.uniprot.org/core/title | "B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cells."xsd:string |
| http://purl.uniprot.org/citations/17023586 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/17023586 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17023586 |
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