| http://purl.uniprot.org/citations/17023658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17023658 | http://www.w3.org/2000/01/rdf-schema#comment | "TFII-I is a transcription factor and a target of phosphorylation by Bruton's tyrosine kinase. In humans, deletions spanning the TFII-I locus are associated with a cognitive defect, the Williams-Beuren cognitive profile. We report an unanticipated role of TFII-I outside the nucleus as a negative regulator of agonist-induced calcium entry (ACE) that suppresses surface accumulation of TRPC3 (transient receptor potential C3) channels. Inhibition of ACE by TFII-I requires phosphotyrosine residues that engage the SH2 (Src-homology 2) domains of phospholipase C-g (PLC-g) and an interrupted, pleckstrin homology (PH)-like domain that binds the split PH domain of PLC-g. Our observations suggest a model in which TFII-I suppresses ACE by competing with TRPC3 for binding to PLC-g."xsd:string |
| http://purl.uniprot.org/citations/17023658 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1127815"xsd:string |
| http://purl.uniprot.org/citations/17023658 | http://purl.uniprot.org/core/author | "Snyder S.H."xsd:string |
| http://purl.uniprot.org/citations/17023658 | http://purl.uniprot.org/core/author | "Desiderio S."xsd:string |
| http://purl.uniprot.org/citations/17023658 | http://purl.uniprot.org/core/author | "Patterson R.L."xsd:string |
| http://purl.uniprot.org/citations/17023658 | http://purl.uniprot.org/core/author | "van Rossum D.B."xsd:string |
| http://purl.uniprot.org/citations/17023658 | http://purl.uniprot.org/core/author | "Caraveo G."xsd:string |
| http://purl.uniprot.org/citations/17023658 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17023658 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/17023658 | http://purl.uniprot.org/core/pages | "122-125"xsd:string |
| http://purl.uniprot.org/citations/17023658 | http://purl.uniprot.org/core/title | "Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry."xsd:string |
| http://purl.uniprot.org/citations/17023658 | http://purl.uniprot.org/core/volume | "314"xsd:string |
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