| http://purl.uniprot.org/citations/17024186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17024186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17024186 | http://www.w3.org/2000/01/rdf-schema#comment | "The protein factor U2 snRNP Auxiliary Factor (U2AF) 65 is an essential component required for splicing and involved in the coupling of splicing and 3' end processing of vertebrate pre-mRNAs. Here we have addressed the mechanisms by which U2AF 65 stimulates pre-mRNA 3' end processing. We identify an arginine/serine-rich region of U2AF 65 that mediates an interaction with an RS-like alternating charge domain of the 59 kDa subunit of the human cleavage factor I (CF I(m)), an essential 3' processing factor that functions at an early step in the recognition of the 3' end processing signal. Tethered functional analysis shows that the U2AF 65/CF I(m) 59 interaction stimulates in vitro 3' end cleavage and polyadenylation. These results therefore uncover a direct role of the U2AF 65/CF I(m) 59 interaction in the functional coordination of splicing and 3' end processing."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601331"xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601331"xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Keller W."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Keller W."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Dettwiler S."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Dettwiler S."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Loulergue C."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Loulergue C."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Antoniou M."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Antoniou M."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Karaa S.Z."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Karaa S.Z."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Millevoi S."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Millevoi S."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Vagner S."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/author | "Vagner S."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/pages | "4854-4864"xsd:string |
| http://purl.uniprot.org/citations/17024186 | http://purl.uniprot.org/core/pages | "4854-4864"xsd:string |