| http://purl.uniprot.org/citations/17028303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17028303 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated association between polymorphisms in DNA repair genes and the capacity to repair DNA damage induced by gamma-irradiation and by base oxidation in a healthy population. Irradiation-specific DNA repair rates were significantly decreased in individuals with XRCC1 Arg399Gln homozygous variant genotype (0.45 +/-0.47 SSB/10(9) Da) than in those with wild-type genotype (1.10 +/-0.70 SSB/10(9) Da, P=0.0006, Mann-Witney U-test). The capacity to repair oxidative DNA damage was significantly decreased among individuals with hOGG1 Ser326Cys homozygous variant genotype (0.37 +/-0.28 SSB/10(9) Da) compared to those with wild-type genotype (0.83 +/-0.79 SSB/10(9) Da, P=0.008, Mann-Witney U-test). Investigation of genotype combinations showed that the increasing number of variant alleles for both XRCC1 Arg399Gln and APE1 Asn148Glu polymorphisms resulted in a significant decrease of irradiation-specific repair rates (P=0.008, Kruskal-Wallis test). Irradiation-specific DNA repair rates also decreased with increasing number of variant alleles in XRCC1 Arg399Gln in combination with variant alleles for two other XRCC1 polymorphisms, Arg194Trp and Arg280His (P=0.002 and P=0.005, respectively; Kruskal-Wallis test). In a binary combination variant alleles of hOGG1 Ser326Cys and APE1 Asn148Glu polymorphisms were associated with a significant decrease in the capacity to repair DNA oxidative damage (P=0.018, Kruskal-Wallis test). In summary, XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms seem to exert the predominant modulating effect on irradiation-specific DNA repair capacity and the capacity to repair DNA oxidative damage, respectively."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgl187"xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "Kumar R."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "Soucek P."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "Hemminki K."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "Vodicka P."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "Vodickova L."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "De Palma G."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "Musak L."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "Naccarati A."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "Stetina R."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "Hanova M."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "Pardini B."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "Polakova V."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "Slyskova J."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/author | "Tulupova E."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/pages | "657-664"xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/title | "Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects."xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/17028303 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17028303 |
| http://purl.uniprot.org/citations/17028303 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17028303 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DGK8-mappedCitation-17028303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17028303 |