| http://purl.uniprot.org/citations/17029562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17029562 | http://www.w3.org/2000/01/rdf-schema#comment | "Transposable elements are potent agents of genomic change during evolution, but require access to chromatin for insertion-and not all genes provide equivalent access. To test whether the regulatory features of heat-shock genes render their proximal promoters especially susceptible to the insertion of transposable elements in nature, we conducted an unbiased screen of the proximal promoters of 18 heat-shock genes in 48 natural populations of Drosophila. More than 200 distinctive transposable elements had inserted into these promoters; greater than 96% are P elements. By contrast, few or no P element insertions segregate in natural populations in a "negative control" set of proximal promoters lacking the distinctive regulatory features of heat-shock genes. P element transpositions into these same genes during laboratory mutagenesis recapitulate these findings. The natural P element insertions cluster in specific sites in the promoters, with up to eight populations exhibiting P element insertions at the same position; laboratory insertions are into similar sites. By contrast, a "positive control" set of promoters resembling heat-shock promoters in regulatory features harbors few P element insertions in nature, but many insertions after experimental transposition in the laboratory. We conclude that the distinctive regulatory features that typify heat-shock genes (in Drosophila) are especially prone to mutagenesis via P elements in nature. Thus in nature, P elements create significant and distinctive variation in heat-shock genes, upon which evolutionary processes may act."xsd:string |
| http://purl.uniprot.org/citations/17029562 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.0020165"xsd:string |
| http://purl.uniprot.org/citations/17029562 | http://purl.uniprot.org/core/author | "Chen B."xsd:string |
| http://purl.uniprot.org/citations/17029562 | http://purl.uniprot.org/core/author | "Feder M.E."xsd:string |
| http://purl.uniprot.org/citations/17029562 | http://purl.uniprot.org/core/author | "Walser J.C."xsd:string |
| http://purl.uniprot.org/citations/17029562 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17029562 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/17029562 | http://purl.uniprot.org/core/pages | "e165"xsd:string |
| http://purl.uniprot.org/citations/17029562 | http://purl.uniprot.org/core/title | "Heat-shock promoters: targets for evolution by P transposable elements in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/17029562 | http://purl.uniprot.org/core/volume | "2"xsd:string |
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