| http://purl.uniprot.org/citations/17034582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17034582 | http://www.w3.org/2000/01/rdf-schema#comment | "The human neuromuscular disease myasthenia gravis (MG) is characterized by the generation of autoantibodies reactive with nicotinic acetylcholine receptors (AChR) that cause loss of AChR from the neuromuscular end-plate with resultant failure of neuromuscular transmission. A role for complement (C) in AChR loss has been suggested based upon morphological identification of C at the end-plate in MG and from the effects of C inhibition in murine models. Here we provide further evidence implicating C, and specifically the membrane attack complex (MAC), in a mouse model of MG. Mice deficient in the C regulators Daf1 and/or Cd59a were tested in the model. Wild-type mice were resistant to disease while mice deficient in Daf1 had mild disease symptoms with evidence of C activation and AChR loss at end-plates. Cd59a-deficient mice had very mild disease with some muscle inflammation and essentially undamaged end-plates. In contrast, mice deficient in both C regulators developed a severe paralytic disease with marked muscle inflammation and loss of end-plates. Inhibition of MAC assembly abrogated clinical disease in these double-deficient mice, demonstrating conclusively that MAC formation was driving pathology in the model. These findings provoke us to suggest that current anti-C therapeutics targeting MAC assembly will be beneficial in MG patients resistant to conventional therapies."xsd:string |
| http://purl.uniprot.org/citations/17034582 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2249.2006.03205.x"xsd:string |
| http://purl.uniprot.org/citations/17034582 | http://purl.uniprot.org/core/author | "Mizuno M."xsd:string |
| http://purl.uniprot.org/citations/17034582 | http://purl.uniprot.org/core/author | "Song W."xsd:string |
| http://purl.uniprot.org/citations/17034582 | http://purl.uniprot.org/core/author | "Harris C.L."xsd:string |
| http://purl.uniprot.org/citations/17034582 | http://purl.uniprot.org/core/author | "Morgan B.P."xsd:string |
| http://purl.uniprot.org/citations/17034582 | http://purl.uniprot.org/core/author | "Neal J.W."xsd:string |
| http://purl.uniprot.org/citations/17034582 | http://purl.uniprot.org/core/author | "Chamberlain-Banoub J."xsd:string |
| http://purl.uniprot.org/citations/17034582 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17034582 | http://purl.uniprot.org/core/name | "Clin Exp Immunol"xsd:string |
| http://purl.uniprot.org/citations/17034582 | http://purl.uniprot.org/core/pages | "294-302"xsd:string |
| http://purl.uniprot.org/citations/17034582 | http://purl.uniprot.org/core/title | "The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice."xsd:string |
| http://purl.uniprot.org/citations/17034582 | http://purl.uniprot.org/core/volume | "146"xsd:string |
| http://purl.uniprot.org/citations/17034582 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17034582 |
| http://purl.uniprot.org/citations/17034582 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17034582 |
| http://purl.uniprot.org/uniprot/#_A2BI31-mappedCitation-17034582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17034582 |
| http://purl.uniprot.org/uniprot/#_F7BP06-mappedCitation-17034582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17034582 |
| http://purl.uniprot.org/uniprot/#_Q61475-mappedCitation-17034582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17034582 |
| http://purl.uniprot.org/uniprot/#_O55186-mappedCitation-17034582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17034582 |
| http://purl.uniprot.org/uniprot/#_Q9R1C3-mappedCitation-17034582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17034582 |
| http://purl.uniprot.org/uniprot/F7BP06 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17034582 |
| http://purl.uniprot.org/uniprot/Q61475 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17034582 |
| http://purl.uniprot.org/uniprot/Q9R1C3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17034582 |
| http://purl.uniprot.org/uniprot/A2BI31 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17034582 |