| http://purl.uniprot.org/citations/17035635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17035635 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular signal-regulated kinase (ERK)1/2 activity is reported to be required in mammalian cells for timely entry into and exit from mitosis (i.e., the G2-mitosis [G2/M] and metaphase-anaphase [M/A] transitions). However, it is unclear whether this involvement reflects a direct requirement for ERK1/2 activity during these transitions or for activating gene transcription programs at earlier stages of the cell cycle. To examine these possibilities, we followed live cells in which ERK1/2 activity was inhibited through late G2 and mitosis. We find that acute inhibition of ERK1/2 during late G2 and through mitosis does not affect the timing of the G2/M or M/A transitions in normal or transformed human cells, nor does it impede spindle assembly, inactivate the p38 stress-activated checkpoint during late G2 or the spindle assembly checkpoint during mitosis. Using CENP-F as a marker for progress through G2, we also show that sustained inhibition of ERK1/2 transiently delays the cell cycle in early/mid-G2 via a p53-dependent mechanism. Together, our data reveal that ERK1/2 activity is required in early G2 for a timely entry into mitosis but that it does not directly regulate cell cycle progression from late G2 through mitosis in normal or transformed mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/17035635 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e06-04-0284"xsd:string |
| http://purl.uniprot.org/citations/17035635 | http://purl.uniprot.org/core/author | "Shinohara M."xsd:string |
| http://purl.uniprot.org/citations/17035635 | http://purl.uniprot.org/core/author | "Rieder C.L."xsd:string |
| http://purl.uniprot.org/citations/17035635 | http://purl.uniprot.org/core/author | "Aguirre-Ghiso J.A."xsd:string |
| http://purl.uniprot.org/citations/17035635 | http://purl.uniprot.org/core/author | "Mikhailov A.V."xsd:string |
| http://purl.uniprot.org/citations/17035635 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17035635 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/17035635 | http://purl.uniprot.org/core/pages | "5227-5240"xsd:string |
| http://purl.uniprot.org/citations/17035635 | http://purl.uniprot.org/core/title | "Extracellular signal-regulated kinase 1/2 activity is not required in mammalian cells during late G2 for timely entry into or exit from mitosis."xsd:string |
| http://purl.uniprot.org/citations/17035635 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/17035635 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17035635 |
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| http://purl.uniprot.org/uniprot/#_B4DHN0-mappedCitation-17035635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17035635 |
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