| http://purl.uniprot.org/citations/17041850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17041850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17041850 | http://www.w3.org/2000/01/rdf-schema#comment | "Burkholderia pseudomallei is the etiological agent of melioidosis, a serious human disease for which no vaccine is available. Immunization of susceptible BALB/c mice with the live attenuated mutant B. pseudomallei ilvI (referred to as "2D2") generated significant, although incomplete, immunity. Splenic B. pseudomallei-specific T cells, detected in immunized mice, proliferated and produced interferon-gamma in vitro in response to dead bacteria. Assessment of T cell antigen specificity indicated that subpopulations of B. pseudomallei-reactive T cells were responsive to BopE, a type III secretion system (TTSS) effector protein, and to a lesser extent to BipD, a TTSS translocator protein. Increased survival of severe combined immunodeficient mice adoptively transferred with T cells from immunized mice, compared with that of naive T cell recipients, demonstrated that immunization with 2D2 generated T cell-mediated immunity. CD4+ and CD8+ cell depletion studies demonstrated that CD4+ cells, but not CD8+ cells, mediated this protection in vivo. Thus, CD4+ T cells can mediate vaccine-induced immunity to experimental melioidosis."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.org/dc/terms/identifier | "doi:10.1086/508217"xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.org/dc/terms/identifier | "doi:10.1086/508217"xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Atkins T."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Atkins T."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Haque A."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Haque A."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Galyov E.E."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Galyov E.E."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Titball R."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Titball R."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Stevens M.P."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Stevens M.P."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Bancroft G.J."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Bancroft G.J."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Chu K."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Chu K."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Easton A."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/author | "Easton A."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/name | "J. Infect. Dis."xsd:string |
| http://purl.uniprot.org/citations/17041850 | http://purl.uniprot.org/core/name | "J. Infect. Dis."xsd:string |