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http://purl.uniprot.org/citations/17044080http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17044080http://www.w3.org/2000/01/rdf-schema#comment"

Background

Variation in the expression of plasminogen activator inhibitor type-1 (PAI-1) is associated with many human diseases, including several types of cancer. In particular, tumor cell overexpression of PAI-1 has been found to inhibit prostate cancer tumor growth, angiogenesis, and metastasis in mouse models. Normal host cell expression of PAI-1 is influenced by the 4G/5G insertion/deletion polymorphism in the promoter region of the PAI-1 gene. To evaluate the effect of PAI-1 expression on cancer development, we examined the association of the 4G/5G polymorphism in a sibling-based case-control study of prostate cancer.

Methods

One thousand one hundred thirty seven subjects, 655 cases, and 482 sibling controls from 526 families, were recruited from the major medical institutions in the greater Cleveland, OH area and from the Henry Ford Health System, Detroit, MI. A Cox age-of-onset model with robust variance estimation was used to evaluate the association between the PAI-1 4G/5G polymorphism and prostate cancer.

Results

No association was observed between the PAI-1 4G/5G polymorphism and prostate cancer in the entire sample. We did, however, identify a statistically significant association between the PAI-1 4G/5G polymorphism and prostate cancer in subjects with a family history of this disease (OR = 1.28, 95% CI 1.02-1.61, P-value = 0.036). The PAI-1 5G/5G genotype, associated with lower PAI-1 expression, appears to drive this result as it was associated with an increased risk of prostate cancer and an earlier mean age of onset compared to those with the 4G/4G genotype (OR = 1.83, 95% CI 1.12-2.99) while the 4G/5G genotype group did not show a significant difference in prostate cancer risk compared to the 4G/4G genotype group (OR = 0.98, 95% CI 0.75-1.28).

Conclusions

These observations suggest that the 4G/5G polymorphism in PAI-1 may explain some of the increased risk and earlier mean age of onset of prostate cancer due to a positive family history."xsd:string
http://purl.uniprot.org/citations/17044080http://purl.org/dc/terms/identifier"doi:10.1002/pros.20512"xsd:string
http://purl.uniprot.org/citations/17044080http://purl.uniprot.org/core/author"Liu X."xsd:string
http://purl.uniprot.org/citations/17044080http://purl.uniprot.org/core/author"Casey G."xsd:string
http://purl.uniprot.org/citations/17044080http://purl.uniprot.org/core/author"Jorgenson E."xsd:string
http://purl.uniprot.org/citations/17044080http://purl.uniprot.org/core/author"Cicek M."xsd:string
http://purl.uniprot.org/citations/17044080http://purl.uniprot.org/core/author"Plummer S."xsd:string
http://purl.uniprot.org/citations/17044080http://purl.uniprot.org/core/author"Witte J.S."xsd:string
http://purl.uniprot.org/citations/17044080http://purl.uniprot.org/core/author"Deitcher S.R."xsd:string
http://purl.uniprot.org/citations/17044080http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17044080http://purl.uniprot.org/core/name"Prostate"xsd:string
http://purl.uniprot.org/citations/17044080http://purl.uniprot.org/core/pages"172-177"xsd:string
http://purl.uniprot.org/citations/17044080http://purl.uniprot.org/core/title"Plasminogen activator inhibitor type-1 (PAI-1) polymorphism 4G/5G is associated with prostate cancer among men with a positive family history."xsd:string
http://purl.uniprot.org/citations/17044080http://purl.uniprot.org/core/volume"67"xsd:string
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