| http://purl.uniprot.org/citations/17045351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17045351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17045351 | http://www.w3.org/2000/01/rdf-schema#comment | "By yeast two-hybrid screening using the calcium-binding protein ALG-2 as bait a new target of ALG-2 was identified, the RNA-binding protein RBM22. In order to confirm these interactions in vivo we prepared fluorescent constructs by using the monomeric red fluorescent protein to label ALG-2 and the enhanced green fluorescent protein to label RBM22. Confocal microscopy of NIH 3T3 cells transfected with either ALG-2 or RBM22 expression constructs encoding fluorescent fusion proteins alone revealed that the majority of ALG-2 was localized in the cytoplasm whereas RBM22 was located in the nucleus. When cells were co-transfected with expression vectors encoding both fusion proteins ALG-2 was found in the nucleus indicating that RBM22 which can shuttle between the cytoplasm and the nucleus may play a role in nuclear translocation of ALG-2. Using zebrafish as a model mRNA homologues of ALG-2 and RBM22 were microinjected into the blastodisc-yolk margin of zebrafish embryos at the 1-cell stage followed by monitoring the fusion proteins during development of the zebrafish. Hereby, we observed that ALG-2 alone evenly distributed within the cell, whereas in the presence of RBM22 the two proteins co-localized within the nucleus. More than 95% of the two proteins co-localized within the same area in the nucleus suggesting a functional interaction between the Ca(2+)-signaling protein ALG-2 and the RNA-binding protein RBM22."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2006.09.003"xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2006.09.003"xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Dai Y."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Dai Y."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Becker S."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Becker S."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Miller A.L."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Miller A.L."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Cheung C.Y."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Cheung C.Y."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Michalak M."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Michalak M."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Krebs J."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Krebs J."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Giller K."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Giller K."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Montaville P."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Montaville P."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Webb S.E."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/author | "Webb S.E."xsd:string |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17045351 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |