| http://purl.uniprot.org/citations/17045571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17045571 | http://www.w3.org/2000/01/rdf-schema#comment | "Estrogens can stimulate the proliferation of estrogen-responsive breast cancer cells by increasing their proliferative response to insulin-like growth factors. With a view to investigating the molecular mechanisms implicated, we studied the effect of estradiol on the expression of proteins implicated in the insulin-like growth factor signalling pathway. Estradiol dose- and time-dependently increased the expression of insulin receptor substrate-1 and the p85/p110 subunits of phosphatidylinositol 3-kinase but did not change those of ERK2 and Akt/PKB. ICI 182,780 did not inhibit estradiol-induced IRS-1 and p85 expression. Moreover, two distinct estradiol-BSA conjugate compounds were as effective as estradiol in inducing IRS-1 and p85/p110 expression indicating the possible implication of an estradiol membrane receptor. Comparative analysis of steroids-depleted and steroids-treated cells showed that IGF-I only stimulates cell growth in the latter condition. Nevertheless, expression of a constitutively active form of PI 3-kinase in steroid-depleted cells triggers proliferation. These results demonstrate that estradiol positively regulates essential proteins of the IGF signalling pathway and put in evidence that phosphatidylinositol 3-kinase plays a central role in the synergistic pro-proliferative action of estradiol and IGF-I."xsd:string |
| http://purl.uniprot.org/citations/17045571 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.09.116"xsd:string |
| http://purl.uniprot.org/citations/17045571 | http://purl.uniprot.org/core/author | "Legay C."xsd:string |
| http://purl.uniprot.org/citations/17045571 | http://purl.uniprot.org/core/author | "Bernard L."xsd:string |
| http://purl.uniprot.org/citations/17045571 | http://purl.uniprot.org/core/author | "Adriaenssens E."xsd:string |
| http://purl.uniprot.org/citations/17045571 | http://purl.uniprot.org/core/author | "Ricort J.M."xsd:string |
| http://purl.uniprot.org/citations/17045571 | http://purl.uniprot.org/core/author | "Mougel A."xsd:string |
| http://purl.uniprot.org/citations/17045571 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17045571 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17045571 | http://purl.uniprot.org/core/pages | "916-921"xsd:string |
| http://purl.uniprot.org/citations/17045571 | http://purl.uniprot.org/core/title | "Estradiol regulates the insulin-like growth factor-I (IGF-I) signalling pathway: a crucial role of phosphatidylinositol 3-kinase (PI 3-kinase) in estrogens requirement for growth of MCF-7 human breast carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/17045571 | http://purl.uniprot.org/core/volume | "350"xsd:string |
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