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| http://purl.uniprot.org/citations/17046694 | http://www.w3.org/2000/01/rdf-schema#comment | "It is well established that ligand-gated chloride flux across the plasma membrane modulates neuronal excitability. We find that a voltage-dependent Cl(-) conductance increases neuronal excitability in immature rodents as well, enhancing the time course of NMDA receptor-mediated miniature excitatory postsynaptic potentials (mEPSPs). This Cl(-) conductance is activated by CaMKII, is electrophysiologically identical to the CaMKII-activated CLC-3 conductance in nonneuronal cells, and is absent in clc-3(-/-) mice. Systematically decreasing [Cl(-)](i) to mimic postnatal [Cl(-)](i) regulation progressively decreases the amplitude and decay time constant of spontaneous mEPSPs. This Cl(-)-dependent change in synaptic strength is absent in clc-3(-/-) mice. Using surface biotinylation, immunohistochemistry, electron microscopy, and coimmunoprecipitation studies, we find that CLC-3 channels are localized on the plasma membrane, at postsynaptic sites, and in association with NMDA receptors. This is the first demonstration that a voltage-dependent chloride conductance modulates neuronal excitability. By increasing postsynaptic potentials in a Cl(-) dependent fashion, CLC-3 channels regulate neuronal excitability postsynaptically in immature neurons."xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2006.08.035"xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/author | "Huang P."xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/author | "Marks J.D."xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/author | "Nelson D.J."xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/author | "Kaetzel M.A."xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/author | "Wang X.Q."xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/author | "Lamb F.S."xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/author | "Bindokas V."xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/author | "Deriy L.V."xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/author | "Foss S."xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/pages | "321-333"xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/title | "CLC-3 channels modulate excitatory synaptic transmission in hippocampal neurons."xsd:string |
| http://purl.uniprot.org/citations/17046694 | http://purl.uniprot.org/core/volume | "52"xsd:string |
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