| http://purl.uniprot.org/citations/17047155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17047155 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspases have demonstrated several nonapoptotic functions including a role in the differentiation of specific cell types. Here, we show that caspase-8 is the upstream enzyme in the proteolytic caspase cascade whose activation is required for the differentiation of peripheral-blood monocytes into macrophages. On macrophage colony-stimulating factor (M-CSF) exposure, caspase-8 associates with the adaptor protein Fas-associated death domain (FADD), the serine/threonine kinase receptor-interacting protein 1 (RIP1) and the long isoform of FLICE-inhibitory protein FLIP. Overexpression of FADD accelerates the differentiation process that does not involve any death receptor. Active caspase-8 cleaves RIP1, which prevents sustained NF-kappaB activation, and activates downstream caspases. Together these data identify a role for caspase-8 in monocytes undergoing macrophagic differentiation, that is, the enzyme activated in an atypical complex down-regulates NF-kappaB activity through RIP1 cleavage."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-03-011585"xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/author | "Grant S."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/author | "Micheau O."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/author | "Solary E."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/author | "Fontenay M."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/author | "Cathelin S."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/author | "Launay S."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/author | "Rebe C."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/author | "Dubart-Kupperschmitt A."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/author | "Gyan E."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/author | "Filomenko R."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/author | "Prevotat L."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/author | "L'Ollivier C."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/pages | "1442-1450"xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/title | "Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation."xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/17047155 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17047155 |
| http://purl.uniprot.org/citations/17047155 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17047155 |
| http://purl.uniprot.org/uniprot/Q14790#attribution-700F1B817B361AEAD6D8EC23B4AC6F4E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17047155 |
| http://purl.uniprot.org/uniprot/Q13158#attribution-700F1B817B361AEAD6D8EC23B4AC6F4E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17047155 |
| http://purl.uniprot.org/uniprot/Q13546#attribution-700F1B817B361AEAD6D8EC23B4AC6F4E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17047155 |