| http://purl.uniprot.org/citations/17049054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17049054 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-18 is predominantly a macrophage-derived cytokine with a key role in inflammation and cell-mediated immunity. Having previously demonstrated IL-18 upregulation in a rat model of kidney rejection, here we examined IL-18 in a fully MHC-mismatched murine model of acute kidney rejection using IL-18-deficient recipients (IL-18-/-) and animals administered neutralizing IL-18 binding protein (IL-18BP). Gene expression of IL-18 and its receptor were significantly upregulated in allografts compared to isografts, as was the cellular infiltrate (T cells and macrophages) (p < 0.001). Allografts developed kidney dysfunction (p < 0.05) and tubulitis (p < 0.01) not observed in controls. There was a significant reduction in gene expression of IL-18 downstream pro-inflammatory molecules (iNOS, TNFalpha and IFNgamma) in IL-18-/-recipients (p < 0.01), and IL-18BP-treated animals. The CD4+ infiltrate and IL-4 mRNA expression was greater in the IL-18-/-recipients than wild-type (WT) allografts and IL-18BP-treated animals (p < 0.05), suggesting a Th2-bias which was supported by IFNgamma and IL-4 ELISPOT data and an increased eosinophil accumulation (p < 0.001). Neither IL-18 deficiency nor neutralization prevented renal dysfunction or tubulitis. This study demonstrates increased production of IL-18 in murine kidney allograft rejection and provides evidence that IL-18-induced pathways of inflammation are active. However, neither IL-18 deficiency nor neutralization was protective against the development of allograft rejection."xsd:string |
| http://purl.uniprot.org/citations/17049054 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-6143.2006.01536.x"xsd:string |
| http://purl.uniprot.org/citations/17049054 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/17049054 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/17049054 | http://purl.uniprot.org/core/author | "Yin J."xsd:string |
| http://purl.uniprot.org/citations/17049054 | http://purl.uniprot.org/core/author | "Chadban S."xsd:string |
| http://purl.uniprot.org/citations/17049054 | http://purl.uniprot.org/core/author | "Eris J."xsd:string |
| http://purl.uniprot.org/citations/17049054 | http://purl.uniprot.org/core/author | "Wyburn K."xsd:string |
| http://purl.uniprot.org/citations/17049054 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17049054 | http://purl.uniprot.org/core/name | "Am J Transplant"xsd:string |
| http://purl.uniprot.org/citations/17049054 | http://purl.uniprot.org/core/pages | "2612-2621"xsd:string |
| http://purl.uniprot.org/citations/17049054 | http://purl.uniprot.org/core/title | "Interleukin-18 affects local cytokine expression but does not impact on the development of kidney allograft rejection."xsd:string |
| http://purl.uniprot.org/citations/17049054 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/17049054 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17049054 |
| http://purl.uniprot.org/citations/17049054 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17049054 |
| http://purl.uniprot.org/uniprot/#_A0A1L1STF5-mappedCitation-17049054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17049054 |
| http://purl.uniprot.org/uniprot/#_A0PJ18-mappedCitation-17049054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17049054 |
| http://purl.uniprot.org/uniprot/#_P70380-mappedCitation-17049054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17049054 |
| http://purl.uniprot.org/uniprot/#_K3W4N2-mappedCitation-17049054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17049054 |
| http://purl.uniprot.org/uniprot/#_Q2PMY2-mappedCitation-17049054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17049054 |
| http://purl.uniprot.org/uniprot/#_Q80SS8-mappedCitation-17049054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17049054 |
| http://purl.uniprot.org/uniprot/#_Q6USQ6-mappedCitation-17049054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17049054 |
| http://purl.uniprot.org/uniprot/Q6USQ6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17049054 |
| http://purl.uniprot.org/uniprot/P70380 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17049054 |