| http://purl.uniprot.org/citations/17049405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17049405 | http://www.w3.org/2000/01/rdf-schema#comment | "Analysis of actin remodeling in live cells and tissues has become an increasingly important tool to study actin-dependent cellular processes. To facilitate these experiments in the mouse we have generated a GFP-actin-expressing line (huGE) by knock-in of the GFP-actin gene into the profilin 1 locus. Here we show that GFP-actin is expressed throughout embryonic development and in all tissues except skeletal muscle, in a pattern similar to profilin 1. Particularly high expression of GFP-actin was observed in bone marrow and all blood cells. The GFP-actin fusion protein is functional as shown by its co-localization with endogenous actin in F-actin-rich structures. Therefore, the huGE mouse line provides a novel tool to monitor actin dynamics in mouse embryos and a wide range of organs."xsd:string |
| http://purl.uniprot.org/citations/17049405 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejcb.2006.08.007"xsd:string |
| http://purl.uniprot.org/citations/17049405 | http://purl.uniprot.org/core/author | "Witke W."xsd:string |
| http://purl.uniprot.org/citations/17049405 | http://purl.uniprot.org/core/author | "Gurniak C.B."xsd:string |
| http://purl.uniprot.org/citations/17049405 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17049405 | http://purl.uniprot.org/core/name | "Eur J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17049405 | http://purl.uniprot.org/core/pages | "3-12"xsd:string |
| http://purl.uniprot.org/citations/17049405 | http://purl.uniprot.org/core/title | "HuGE, a novel GFP-actin-expressing mouse line for studying cytoskeletal dynamics."xsd:string |
| http://purl.uniprot.org/citations/17049405 | http://purl.uniprot.org/core/volume | "86"xsd:string |
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