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http://purl.uniprot.org/citations/17050029http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17050029http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17050029http://www.w3.org/2000/01/rdf-schema#comment"

Background/aims

The hepatitis B virus (HBV) genotype C is associated with the development of hepatocellular carcinoma (HCC). In addition, the HBV X gene, which encodes the pleiotropic transactivator HBx, has also been associated with the development of HCC. In this study, we investigated whether nucleotide changes in the X gene of genotype C are associated with the development of HCC.

Methods/results

We sequenced the X gene in age- and sex-matched 39 HBV-infected patients with HCC and 36 HBV-infected patients without HCC. A novel nucleotide change that resulted in a proline to serine substitution at codon 38 in HBx (codon-38 change) was preferentially found in patients with HCC. Then, sera were collected from a new group of age- and sex-matched 52 patients with HCC and 51 patients without HCC. In this cohort also, the codon-38 change was associated with HCC. Multiple logistic regression analysis showed the prevalence of the codon-38 change was significantly associated with HCC in all patients (P=0.001, odds ratio: 4.89).

Conclusion

The codon-38 change in genotype C is an independent risk factor for the development of HCC and may serve as a useful molecular marker for predicting the clinical outcomes in patients infected with HBV."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.org/dc/terms/identifier"doi:10.1016/j.jhep.2006.07.025"xsd:string
http://purl.uniprot.org/citations/17050029http://purl.org/dc/terms/identifier"doi:10.1016/j.jhep.2006.07.025"xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Kato N."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Kato N."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Ohta M."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Ohta M."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Moriyama M."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Moriyama M."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Tanaka Y."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Tanaka Y."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Yoshida H."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Yoshida H."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Fukai K."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Fukai K."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Shiratori Y."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Shiratori Y."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Shiina S."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Shiina S."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Imazeki F."xsd:string
http://purl.uniprot.org/citations/17050029http://purl.uniprot.org/core/author"Imazeki F."xsd:string
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