| http://purl.uniprot.org/citations/17050680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17050680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17050680 | http://www.w3.org/2000/01/rdf-schema#comment | "The RIG-G gene, originally isolated from an acute promyelocytic leukemia cell line NB4, codes for a 60-kDa cytoplasmic protein that is induced by all-trans retinoic acid (ATRA) treatment along with the induction of morphological differentiation of NB4 cells. Here, we provide evidence that ectopic expression of Rig-G in U937 cells can lead to a significant accumulation of cells at G(1)/S transition. Growth arrest seems to occur by modulating several major cell cycle regulatory players. Interestingly, Rig-G alters JAB1 cellular distribution through interacting with this protein and increases the intracellular level of p27 by preventing it from the JAB-1-dependent and ubiquitin/proteasome-mediated degradation. Furthermore, we demonstrate a role of Rig-G for c-myc down-regulation that results in an up-regulation of p21, tightly associated with cell cycle arrest. In addition, our studies reveal that Rig-G is a direct target of STAT1, a key transcription factor in regulating IFN responses, and may be one of the first experimentally proven molecular mediators for the antiproliferative effect of IFN-alpha. Considering that IFN-alpha and ATRA synergistically inhibit growth along the intracellular pathways triggered by the two compounds in many cell types, we suggest that Rig-G may also represent one of the key molecular nodes of signaling cross-talk between ATRA and IFN-alpha."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0607830103"xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0607830103"xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Chen G.Q."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Chen G.Q."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Xiao S."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Xiao S."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Zhu H.Q."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Zhu H.Q."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Chen S.J."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Chen S.J."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Dou A.X."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Dou A.X."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Jia P.M."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Jia P.M."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Pan X.R."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Pan X.R."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Peng L.L."xsd:string |
| http://purl.uniprot.org/citations/17050680 | http://purl.uniprot.org/core/author | "Peng L.L."xsd:string |