| http://purl.uniprot.org/citations/17050694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17050694 | http://www.w3.org/2000/01/rdf-schema#comment | "The telencephalic neuroepithelium (NE) of mammalian brain has an apical-basal polarity that is marked by the positioning of neural progenitors and adherens junctions on the apical/ventricular surface and the ascending of radial glia/progenitor fibers toward the pial/basal surface. The signaling pathway that establishes this apical-basal polarity of NE is not completely understood, but the Rho-family GTPase Cdc42 may play a critical role because it controls cadherin-based intercellular junctions and cell polarity in many species. Here, we tested this hypothesis by a conditional gene-targeting strategy by using the Foxg1-Cre line to delete Cdc42 in the telencephalic neural progenitors in mouse embryos. We found that Cdc42-deletion abolishes the apical localization of PAR6, aPKC, E-cadherin, beta-catenin, and Numb proteins in the NE, and severely impairs the extension of nestin-positive radial fibers. Consequently, neural progenitors were scattered throughout the entire depth of the NE, and the Cdc42-deficient telencephalon failed to bulge or separate into two cerebral hemispheres, resulting in holoprosencephaly. However, neither the midline expression of Sonic hedgehog nor the dorso-ventral patterning of the telencephalon was affected by Cdc42-deletion. Taken together, these results indicate that Cdc42 has an essential role in establishing the apical-basal polarity of the telencephalic NE, which is needed for the expansion and bifurcation of cerebral hemispheres."xsd:string |
| http://purl.uniprot.org/citations/17050694 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0603533103"xsd:string |
| http://purl.uniprot.org/citations/17050694 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/17050694 | http://purl.uniprot.org/core/author | "Liao G."xsd:string |
| http://purl.uniprot.org/citations/17050694 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/17050694 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/17050694 | http://purl.uniprot.org/core/author | "Campbell K."xsd:string |
| http://purl.uniprot.org/citations/17050694 | http://purl.uniprot.org/core/author | "Nakafuku M."xsd:string |
| http://purl.uniprot.org/citations/17050694 | http://purl.uniprot.org/core/author | "Kuan C.Y."xsd:string |
| http://purl.uniprot.org/citations/17050694 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17050694 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/17050694 | http://purl.uniprot.org/core/pages | "16520-16525"xsd:string |
| http://purl.uniprot.org/citations/17050694 | http://purl.uniprot.org/core/title | "Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly."xsd:string |
| http://purl.uniprot.org/citations/17050694 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/17050694 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17050694 |
| http://purl.uniprot.org/citations/17050694 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17050694 |
| http://purl.uniprot.org/uniprot/#_D3Z7I6-mappedCitation-17050694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17050694 |
| http://purl.uniprot.org/uniprot/#_D3Z7J1-mappedCitation-17050694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17050694 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-17050694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17050694 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQV9-mappedCitation-17050694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17050694 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RLU4-mappedCitation-17050694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17050694 |
| http://purl.uniprot.org/uniprot/#_A0A1D5RM76-mappedCitation-17050694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17050694 |
| http://purl.uniprot.org/uniprot/#_D3Z1E8-mappedCitation-17050694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17050694 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-17050694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17050694 |